南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (10): 1123-1125.

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脑心通对大鼠脑缺血海马CA1区神经元损伤的保护作用

朱心红1, 杨建明1, 高天明1,2   

  1. 1. 南方医科大学生理学教研室, 广东, 广州, 510515;
    2. 南方医科大学解剖学教研室, 广东, 广州, 510515
  • 出版日期:2004-10-20 发布日期:2004-10-20
  • 基金资助:
    收稿日期:2004-4-10。
    基金项目:国家自然科学基金(30125013; 30330240; 30371772);广东省自然科学基金(37047);教育部“长江学者”奖励计划
    作者简介:朱心红(1968- ),男,中西医结合临床专业硕士、神经生物学专业博士,主要从事缺血性脑损伤的修复及机制研究
    通讯作者:高天明(1960-),解剖学教研室教育部"长江学者"特聘教授,博士生导师,电话:020-61648216

Neuroprotective effects of Naoxintong against neuronal injury in hippocampal CA1 region following transient forebrain ischemia in rats

ZHU Xin-hong1, YANG Jian-ming1, GAO Tian-ming1,2   

  1. 1. 南方医科大学生理学教研室, 广东, 广州, 510515;
    2. 南方医科大学解剖学教研室, 广东, 广州, 510515
  • Online:2004-10-20 Published:2004-10-20

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摘要： 目的 研究脑心通、中风回春丸对大鼠前脑缺血海马CA1区神经元损伤的保护作用。方法 采用改良的Pulsinelli四血管闭塞法制作前脑缺血模型,光镜下观察并计CA1区存活锥体细胞密度;并与尼莫地平对照。结果 脑心通及尼莫地平灌胃给药组大鼠海马CA1区存活锥体细胞密度明显高于生理盐水组(P<0.05,P<0.001),但脑心通与尼莫地平组之间无明显差异;中风回春丸无明显的神经保护作用。结论 脑心通具有明显的神经保护作用。

Abstract: Objective To examine the neuroprotective effects of Naoxintong and Zhongfenghuichunwan on neuronal injury in CA1 region of rat hippocampus following transient forebrain ischemia.Methods Transient rat forebrain ischemia for 15 min was induced by modified four-vessel occlusion method. The density of survived pyramidal cells (neurons per 1 mm linear length) in CA1 region of the hippocampus was measured under light microscope. Results In Naoxintong or nimodipine-treated rats,the density of survived pyramidal cells in CA1 region was significantly greater than that of saline group (P<0.05,P<0.001,respectively),but oral administration of Zhongfenghuichunwan had no obvious effect on ischemia-induced neuronal damage in CA1 region.Conclusion Naoxintong can protect CA1 neurons against ischemic insult in rats.

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