保和丸剂型改革的提取工艺优化

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (09): 1068-1071.

保和丸剂型改革的提取工艺优化

于红宇¹, 刘中秋², 姚育法³

1. 广州市番禺何贤纪念医院药剂科, 广东, 广州, 511400;
2. 广州中医药大学新药开发中心, 广东, 广州, 510010;
3. 第一军医大学珠江医院药剂科, 广东, 广州, 510282

出版日期:2004-09-20 发布日期:2004-09-20
基金资助:
收稿日期:2004-5-28。
作者简介:于红宇(1962-),男,研究生,副主任药师,主要从事医院药学工作,电话:020-84629993,E-mail:YuHongYu@163.com

Optimization of the extraction process in the traditional preparation of Baohe Wan

YU Hong-yu¹, LIU Zhong-qiu², YAO Yu-fa³

1. 广州市番禺何贤纪念医院药剂科, 广东, 广州, 511400;
2. 广州中医药大学新药开发中心, 广东, 广州, 510010;
3. 第一军医大学珠江医院药剂科, 广东, 广州, 510282

Online:2004-09-20 Published:2004-09-20

摘要/Abstract

摘要： 目的对传统中药保和丸剂型改革的提取工艺进行研究。方法以保和丸中主要成分总黄酮保留率和药效学试验结果为指标,考察不同提取工艺路线的合理性。结果处方中含挥发性成分药材经二氧化碳超临界萃取后,萃取药渣再与其余药材合并水提的工艺路线,总黄酮的提取率和药效最佳。该提取工艺所得剂型在小鼠小肠炭末推进与胃排空等药效学指标上,均优于保和丸。结论超临界二氧化碳萃取和水提相结合的工艺路线,可作为保和丸剂型改革的提取工艺。

Abstract: Objective To study the extraction process for reforming the traditional preparation process of Baohe Wan. Method Using the recovery rate of total flavanoids of Baohe Wan and pharmacodynamic effects as indices, different extraction processes were compared. Results Supercritical carbon dioxide fluid extraction combined with water extraction was optimal for the extraction, and the extract prepared by the new process was pharmacodynamically more potent than the original Baohe Wan, as demonstrated by the rate of carbon powder moving in the small intestine and stomach emptying rate in mice. Conclusion Supercritical carbon dioxide fluid extraction combined with water extraction is practical for optimizing the preparation of Baohe Wan.

中图分类号:

R283.6

于红宇¹, 刘中秋², 姚育法³. 保和丸剂型改革的提取工艺优化[J]. 南方医科大学学报, 2004, 24(09): 1068-1071.

YU Hong-yu¹, LIU Zhong-qiu², YAO Yu-fa³. Optimization of the extraction process in the traditional preparation of Baohe Wan[J]. Journal of Southern Medical University, 2004, 24(09): 1068-1071.

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