湿热环境猫颅脑火器伤早期脑微循环及血脑屏障的变化

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (08): 877-880.

湿热环境猫颅脑火器伤早期脑微循环及血脑屏障的变化

马德选, 徐如祥, 朱红胜

第一军医大学珠江医院全军神经医学研究所, 广东, 广州, 510282

出版日期:2004-08-20 发布日期:2004-08-20
基金资助:
收稿日期:2004-2-25。
基金项目:全军医学科研“九五”杰出人才基金(96M83)
作者简介:马德选(1970-),男,2001年毕业于第一军医大学,硕士,神经外科主治医师,主要从事于颅脑创伤的基础与临床研究

Changes of cat cerebral microcirculation and blood-brain barrier in early stage of craniocerebral gunshot wound in the hot and humid environment

MA De-xuan, XU Ru-xiang, ZHU Hong-sheng

第一军医大学珠江医院全军神经医学研究所, 广东, 广州, 510282

Online:2004-08-20 Published:2004-08-20

摘要/Abstract

摘要： 目的研究湿热环境对猫颅脑火器伤早期脑微循环的影响,为临床治疗提供实验依据。方法 24只成年猫用改良Carey法制作猫颅脑火器伤模型后,随机分为两组,每组12只,放入温度和相对湿度分别为25℃和50%,35℃和85%仿真模拟气候舱。通过脑微血管形态学及通透性和周围组织病理变化的观察,测定生命体征代偿指标、微血管中流动血液流变学特征和血脑屏障的变化来反应脑微循环的变化。结果全部动物无死亡。两组动物在脑微血管形态学及通透性和周围组织病理变化显著;在生命体征指标、血液流变学特征和血脑屏障的损害程度上存在显著差异。结论湿热环境对颅脑火器伤的早期脑微循环有显著影响,是颅脑火器伤的二次创伤。

Abstract: Objective To study the changes of cat cerebral mircocirculation in early stage after craniocerebral gunshot wound in the hot and humid environment to provide laboratory evidence for clinical treatment of such wound. Methods Craniocere- bral gunshot wound was induced in 24 cats according to the method described by Carey with modifications, and the cats were placed in a cabin with environmental temperature and humidity of 25℃ and 50% (group A), and 35℃ and 85% (group B), respectively, to observe the changes in all the indices of cerebral microcirculation. Results All the cats survived and notable changes occurred in the morphology and permeability of cerebral microvascular along with obvious pathological changes in the brain tissue, and the vital signs, hemorheology and blood-brain barrier were significantly different between groups A and B. Conclusion Hot and humid environment induces obvious changes in cat cerebral microcirculation and blood-brain barrier function in the early stages after craniocerebral gunshot wound.

中图分类号:

R826.62

马德选, 徐如祥, 朱红胜. 湿热环境猫颅脑火器伤早期脑微循环及血脑屏障的变化[J]. 南方医科大学学报, 2004, 24(08): 877-880.

MA De-xuan, XU Ru-xiang, ZHU Hong-sheng. Changes of cat cerebral microcirculation and blood-brain barrier in early stage of craniocerebral gunshot wound in the hot and humid environment[J]. Journal of Southern Medical University, 2004, 24(08): 877-880.

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