米非司酮联合氨甲喋呤治疗输卵管异位妊娠

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (07): 829-831.

米非司酮联合氨甲喋呤治疗输卵管异位妊娠

李卓华¹, 全松²

1. 汕头市第二人民医院妇产科, 广东, 汕头, 515011;
2. 第一军医大学南方医院妇产科, 广东, 广州, 510515

出版日期:2004-07-20 发布日期:2004-07-20
基金资助:
收稿日期:2004-1-15。
作者简介:李卓华(1974- ),女,1996年毕业于广州医学院,本科,主治医师,电话:0754-8289126

Mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy

LI Zhuo-hua¹, QUAN Song²

1. 汕头市第二人民医院妇产科, 广东, 汕头, 515011;
2. 第一军医大学南方医院妇产科, 广东, 广州, 510515

Online:2004-07-20 Published:2004-07-20

摘要/Abstract

摘要： 目的探讨米非司酮联合氨甲喋呤治疗输卵管异位妊娠的疗效。方法对早期确诊的102例输卵管异位妊娠患者,口服米非司酮75mg,2次/d,共服3d,另单次肌肉注射氨甲喋呤1mg/kg·b.W.,24h后肌肉注射四氢叶酸钙0.1 mg/kg·b.W.。对照组86例,单次肌肉注射氨甲喋呤1mg/kg·b.w.,24h后肌肉注射四氢叶酸钙0.1 mg/kg·b.w.。结果 94例米非司酮治疗患者治愈率为92.20%。对照组治疗成功70例,治愈率81.4%,两组疗效差异显著(P<0.05)。结论米非司酮联合氨甲喋呤保守治疗输卵管异位妊娠疗效确切,无明显副作用。

Abstract: Objective To observe the effects of mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy. Methods A total of 102 cases of tubal ectopic pregnancy diagnosed at early stage were enrolled to receive oral mefepristone at the dose of 75 mg twice daily for 3 d and intramuscular injection with calcium leucovorin at 0.1 mg/kg 24 h after a single dose of methotrexate injection (1 mg/kg· b.w.). In the control group consisting of 86 similar cases, intramuscular injection with calcium leucovorin at 0.1 mg/kg was given 24 h after a single dose of methotrexate (1 mg/kg·b.w.). Results Ninety-four of the 102 cases (92.20%) receiving oral mifepristone combined with calcium leucovorin and methotrexate were cured, a curative rate significantly higher than that in the control group, where 70 cases (81.4%) were cured (P<0.05). Conclusion Mefepristone combined with methotrexate is safe and effective in the treatment of tubal ectopic pregnancy, without obvious side effects.

中图分类号:

R714.22

李卓华¹, 全松². 米非司酮联合氨甲喋呤治疗输卵管异位妊娠[J]. 南方医科大学学报, 2004, 24(07): 829-831.

LI Zhuo-hua¹, QUAN Song². Mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy[J]. Journal of Southern Medical University, 2004, 24(07): 829-831.

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