鼻咽癌患者微波热疗联合放疗前后T细胞亚群的变化及预后价值

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (07): 818-820.

鼻咽癌患者微波热疗联合放疗前后T细胞亚群的变化及预后价值

裘宇容, 郑磊, 杨春莉, 魏东, 孙德华

第一军医大学南方医院检验科, 广东, 广州, 510515

出版日期:2004-07-20 发布日期:2004-07-20
基金资助:
收稿日期:2004-2-25。
作者简介:裘字容(1963- ),女,1988年毕业于第一军医大学,副主任技师,电话:020-61642145;E-mail:OYR@fimmu.com

Prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma

QIU Yu-rong, ZHENG Lei, YANG Chun-li, WEI Dong, SUN De-hua

第一军医大学南方医院检验科, 广东, 广州, 510515

Online:2004-07-20 Published:2004-07-20

摘要/Abstract

摘要： 目的探讨微波热疗联合放疗前后鼻咽癌患者外周血中T细胞亚群的变化及其预后价值。方法用流式细胞仪检测了20例非癌症患者(对照组)和30例鼻咽癌患者微波热疗联合放疗前后及20例单纯放疗鼻咽癌病人T细胞亚群。结果与对照组相比,鼻咽癌病人外周血CD3⁺CD4⁺细胞百分率及CD8⁺CD28⁺细胞百分率降低(P<0.01),CD3⁺CD8⁺细胞和CD8⁺CD28⁺细胞百分率明显升高(P<0.01),CD4/CD8比值降低(P<0.01)。微波热疗联合放疗后1个月,病人外周血CD3⁺CD4⁺细胞百分率及CD8⁺CD28⁺细胞百分率进一步降低,CD3⁺CD8⁺细胞和CD8⁺CD28^-细胞百分率继续升高,3个月后上述结果仍进一步恶化,且与病人的存活期限有明显关系。结论微波热疗联合放疗后病人的T细胞免疫功能在较长时间内是受抑制的。CD8⁺CD28⁺和CD8⁺CD28^-T细胞亚群的检测对微波热疗联合放疗病人的预后有重要临床意义。

Abstract: Objective To assess the prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma (NPC). Methods Peripheral blood T cell subsets in 20 normal subjects (control group), 30 NPC patients undergoing thermoradiotherapy, and 20 NPC patients undergoing radiotherapy were detected by flow cytometry. Results The percentages of CD3⁺CD4⁺ and CD8⁺CD28⁺ cells were decreased and the percentages of CD3⁺CD8⁺ and CD8⁺CD28^- cells increased as compared with the measurements in normal persons. One month after thermoradiotherapy, the percentages of CD3⁺CD4⁺ and CD8⁺CD28⁺ cells further decreased and the percentages of CD3⁺CD8⁺ and CD8⁺CD28^- cells further increased, which continued to worsen 3 months after the treatment and appeared to be related to the survival of the patients. Conclusion T cell subsets of NPC patients are abnormal and their immune functions depressed in NPC patients within a long period after thermoradio-therapy. CD8⁺CD28⁺ and CD8⁺CD28^- T cell subsets can be significant for prognostic assessment in these patients after ther-moradiotherapy.

中图分类号:

R453
R446.6

裘宇容, 郑磊, 杨春莉, 魏东, 孙德华. 鼻咽癌患者微波热疗联合放疗前后T细胞亚群的变化及预后价值[J]. 南方医科大学学报, 2004, 24(07): 818-820.

QIU Yu-rong, ZHENG Lei, YANG Chun-li, WEI Dong, SUN De-hua. Prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma[J]. Journal of Southern Medical University, 2004, 24(07): 818-820.

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