南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (07): 765-767.

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颅脑火器伤早期脑微血管三维构型和超微结构实验研究

钱畅1, 陈长才2   

  1. 1. 桂林市人民医院神经外科, 广西, 桂林, 541002;
    2. 第一军医大学珠江医院神经外科, 广东, 广州510282
  • 出版日期:2004-07-20 发布日期:2004-07-20
  • 基金资助:
    收稿日期:2004-2-19。
    基金项目:军队九五军事医学科研课题(98M067)
    作者简介:钱畅(1956- ),男,1998年毕业于第一军医大学,医学硕士,副主任医师,现为广西桂林市人民医院院长,电话:0773-2979699

Three-dimensional architecture and ultrastructure of the cerebral microvasculature of missile brain wound in cats

QIAN Chang1, CHEN Chang-cai2   

  1. 1. 桂林市人民医院神经外科, 广西, 桂林, 541002;
    2. 第一军医大学珠江医院神经外科, 广东, 广州510282
  • Online:2004-07-20 Published:2004-07-20

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摘要： 目的 探讨颅脑火器伤早期猫脑微血管三维构型和超微结构变化。方法 应用脑微血管铸型扫描电镜观察伤后脑微血管三维结构的变化,同时行脑超薄切片透射电镜观察微血管内皮细胞和神经细胞结构的变化。结果 颅脑火器伤后,脑微血管发生紊乱,既有血管痉挛又有血管扩张,出血和缺血并存,微血管括约肌出现病理性强力收缩,部分微血管破裂,血管内皮细胞微绒毛、空泡增多,紧密连接增宽,基底膜断裂,血管周围水肿及周围神经细胞损伤。结论 颅脑火器伤早期脑微血管结构出现损害,引起了脑微循环功能紊乱,导致脑的继发性损害。

Abstract: Objective To explore the changes of cerebral microvasculature in cats with missile brain wound. Methods The microvascular corrosion casts of the brain were examined by scanning electron microscopy, and the ultra-thin slices of the brain were inspected by transmission electron microscopy. Results The brain microvasculature showed evidently abnormal morpholo- gical changes, with both vasospasm and vasodilation as well as concurrent bleeding and ischemia. Strong pathological contraction of vascular sphincter, rupture of some microvessels, and increased microvilli and vacuoles in the endothelial cells were observed. Loosening of the intercellular tight junction and basal membrane rupture occurred along with perivascular swelling and neural cell damages. Conclusion Morphological or functional changes occur in the cerebral microvasculature leading to secondary brain injury after missile brain wound in cats.

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