丙型肝炎病毒感染对肾移植术后影响的临床研究

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (06): 682-684.

丙型肝炎病毒感染对肾移植术后影响的临床研究

于立新, 王志鹏, 付绍杰, 王亦斌, 杜传福, 徐健, 邓文锋

第一军医大学南方医院肾移植科, 广东, 广州, 510515

出版日期:2004-06-20 发布日期:2004-06-20
基金资助:
收稿日期:2004-1-6。
作者简介:于立新(1950- ),男,第一军医大学南方医院肾移植科主任,教授、主任医师,电话:020-61641720,E-mail:liuxy@fimmu.com.

Hepatitis C virus infection and clinical outcome of kidney transplantation

YU Li-xin, WANG Zhi-peng, FU Shao-jie, WANG Yi-bin, DU Chu-fu, XU Jian, DENG Wen-feng

第一军医大学南方医院肾移植科, 广东, 广州, 510515

Online:2004-06-20 Published:2004-06-20

摘要/Abstract

摘要： 目的探讨丙型肝炎病毒(Hepatitis C virus,HCV)感染对肾移植术后的影响。方法比较86名HCV感染和86名非HCV感染病人肾移植术后1,3,5年人/肾存活率和急、慢性排斥反应的发生率,并对死亡病例的原因进行分析。结果两组病人在肾移植术后不同时间人/肾的存活率分别为:术后1年(94.2%/90.7%和96.8%/96.0%);术后3年(88.4%/79.1%和90.7%/87.2%);术后5年(74.4%/73.3%和87.2%/81.4%)。两组急性排斥反应发生率为31.3%和21.2%,慢性排斥反应发生率为12.5%和6.5%。其中HCV感染组5年人存活率低于非HCV感染组(P<0.05),而其他各项结果无统计学差异(P>0.05)。肝病为感染组的首位死亡原因(36.4%)。结论 HCV感染对肾移植受者术后长期存活存在负面影响,HCV感染应作为肾移植手术的相对禁忌证。

Abstract: Objective To study the influence of hepatitis C virus (HCV) infection on the clinical outcome of kidney transplan-tation. Methods The recipient/graft survival, the incidence of acute/chronic rejection and cause of death in 86 HCV-infected recipients of renal transplantation were compared with those in another 86 recipients without HCV infection. Results HCV-infected recipients had significantly shorter 5-year survival (74.4%) than those without HCV infection (87.2%, P<0.01). The 1-year (94.2%/90.7% vs 96.8%/96.0%) and 3-year recipient/graft survival rates (88.4%/79.1% vs 90.7%/87.2%), the incidence of acute/chronic rejection (31.3% vs 21.2%, and 12.5% vs 6.5%) and the 5-year graft survival (73.3%/81.4%) were comparable between the two groups (P>0.05). Hepatic disease was identified as the primary cause of mortality. Conclusions HCV infection may affect the long-term survival of the recipients with kidney transplantation, and therefore should be considered as a relative contraindication of kidney transplantation.

中图分类号:

于立新, 王志鹏, 付绍杰, 王亦斌, 杜传福, 徐健, 邓文锋. 丙型肝炎病毒感染对肾移植术后影响的临床研究[J]. 南方医科大学学报, 2004, 24(06): 682-684.

YU Li-xin, WANG Zhi-peng, FU Shao-jie, WANG Yi-bin, DU Chu-fu, XU Jian, DENG Wen-feng. Hepatitis C virus infection and clinical outcome of kidney transplantation[J]. Journal of Southern Medical University, 2004, 24(06): 682-684.

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