南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (05): 591-593.

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碘131治疗重度甲状腺肿大伴机能亢进征38例临床观察

赵永胜, 赵丛雯, 黄铁军, 何蓓, 易炜   

  1. 深圳市第二人民医院核医学科, 广东, 深圳, 518035
  • 出版日期:2004-05-20 发布日期:2004-05-20
  • 基金资助:
    收稿日期:2003-9-26。
    作者简介:赵永胜(1969- ),男,1997年毕业于中山医科大学,硕士,主治医师,电话:0755-26232232,E-mail:szsait@163.com

Iodine-131 therapy for large goiter with hyperthyroidism: clinical observation of 38 cases

ZHAO Yong-sheng, ZHAO Cong-wen, HUANG Tie-jun, HE Bei, YI Wei   

  1. 深圳市第二人民医院核医学科, 广东, 深圳, 518035
  • Online:2004-05-20 Published:2004-05-20

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摘要： 目的 评价碘-131对重度甲状腺肿大伴机能亢进征的疗效和安全性。方法 确诊重度甲状腺肿大伴甲亢后,根据现有公式和触诊经验确定甲状腺质量,按每克甲状腺组织实际投入3.7~5.55 MBq计算治疗剂量,1次口服确定剂量后随访观察治疗效果和副作用,部分病例进行了第2次甚至第3次碘-131治疗。结果 38例患者经过1~3次碘-131治疗后全部获得治愈,其中第1次治愈23例(60.5%),第2次治愈13例(34.2%),第3次治愈2例(5.3%),4例发生甲低(10.5%),无1例患者发生甲亢危象和呼吸困难。结论 碘-131治疗重度甲状腺肿大伴甲亢安全又有效,可以作为常规治疗方法。

Abstract: Objective To evaluate the therapeutic efficacy and safety of iodine-131 therapy for large goiter complicated by hyperthyroidism. Methods After the diagnosis of large goiter complicated by hyperthyroidism was established, the weight of the patient’s thyroid gland was determined, and the doses of iodine-131 calculated according to the formula currently available. After a single dose of oral iodine-131 capsule, the patients were observed for the therapeutic efficacy and side effects. Some patients were given the second or even the third dose of iodine-131. Results All of the 38 patients were cured by 1 to 3 single doses of iodine-131 therapy, of whom 23 (60.5%) needed only a single dose for the cure, 13 (34.2%) required the second dose, and 2 (5.3%) necessitate a third dose. Hypothyroidism occurred in 4 cases (10.5%), and none of the patients developed hyperthyroidism crisis and dyspnea. Conclusions Iodine-131 therapy for serious goiter with hyperthyroidism is safe and effective, which can be used as a routine therapy for this condition.

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