含左氧氟沙星、力克肺疾、微卡方案治疗耐多药肺结核近期疗效观察

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (05): 574-575,578.

含左氧氟沙星、力克肺疾、微卡方案治疗耐多药肺结核近期疗效观察

郑献民, 李松梅, 邢宝春

新乡医学院第一附属医院结核内科, 河南, 卫辉, 453l00

出版日期:2004-05-20 发布日期:2004-05-20
基金资助:
收稿日期:2003-8-2。
作者简介:郑献民(1963- ),男,新乡医学院一附院主治医师,电话:0373-4402542;李松梅,电话:0373-3029321,E-mail:lsf_0309@sohu.com

Short-term effect of treatment protocol utilizing levofloxacin, pasiniazide and M.Vaccae on multi- drug resistant pulmonary tuberculosis

ZHENG Xian-min, LI Song-mei, XING Bao-chun

新乡医学院第一附属医院结核内科, 河南, 卫辉, 453l00

Online:2004-05-20 Published:2004-05-20

摘要/Abstract

摘要： 目的观察含左氧氟沙星、力克肺疾、微卡联合化疗方案对耐多药肺结核(MDR-TB)的疗效。方法将97例MDR-TB患者随机分为治疗组(50例)和对照组(47例),对两组分别以不同的药物进行治疗,疗程均为6个月。观察两组痰菌阴转率、病变吸收率、空洞闭合率以及免疫功能改善情况。结果治疗组与对照组治疗后各项指标分别为:菌阴转率(84% vs 42%)、病灶显效率(83% vs 33%)、空洞闭合率(66% vs 26%)。另外,治疗组CD₃、CD₄较治疗前明显升高;CD₈较治疗前显著降低;CD₄ / CD₈比值升高。两组药物不良反应率无显著性差异(30% vs 38%)。结论应用三药联合化疗方案治疗MDR-TB疗效确切,可进一步应用于临床。

Abstract: Objective To observe the effects of the protocol combining levofloxacin, pasiniazide, M.Vaccae (V+D+M protocol) in the treatment of multi-drug resistant pulmonary tuberculosis (MDR-TB). Method Ninety-seven cases of MDR-TB randomized into V+D+M treatment protocol group (n=50) and control group (n=47) were observed for the negative sputum conversion rate, focal absorption, pulmonary cavity closure and improvement of immune function, after a 6-month treatment course. Results After the completion of the treatment course, the negative sputum conversion rate in V+D+M treatment protocol group was 84%, significantly higher than that in the control group (42%); the former group showed a focal absorption rate and pulmonary cavity closure rate of 83% and 66%, which were 33% and 26% respectively in the latter. In V+D+M treatment protocol group, T lymphocyte subgroups CD₃ and CD₄ were significantly elevated while CD₈ decreased after treatment, resulting in increased CD₄ to CD₈ ratio. The incidence of adverse effects resulting from the different treatment protocols in the two groups were comparable (30% vs 38%). Conclusion V+D+M treatment protocol is effective for MDR-TB, which possesses the potential for application in clinical practice.

中图分类号:

R521

郑献民, 李松梅, 邢宝春. 含左氧氟沙星、力克肺疾、微卡方案治疗耐多药肺结核近期疗效观察[J]. 南方医科大学学报, 2004, 24(05): 574-575,578.

ZHENG Xian-min, LI Song-mei, XING Bao-chun. Short-term effect of treatment protocol utilizing levofloxacin, pasiniazide and M.Vaccae on multi- drug resistant pulmonary tuberculosis[J]. Journal of Southern Medical University, 2004, 24(05): 574-575,578.

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