超声联合微泡对兔股动脉血栓的促溶作用

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (05): 536-538.

超声联合微泡对兔股动脉血栓的促溶作用

区文超, 修建成, 谢晋国, 查道刚, 刘俭, 郝睿, 宾建平, 刘伊丽

第一军医大学南方医院心内科, 广东, 广州, 510515

出版日期:2004-05-20 发布日期:2004-05-20
基金资助:
收稿日期:2003-9-12。
基金项目:国家自然科学基金(30270385);广东省医学科研基金课题(A2003599)
作者简介:区文超(1967- ),男,第一军医大学在读博士研究生,电活:020-61641888-87092

Ultrasound microbubbles promote thrombolysis of rabbit femoral artery thrombus

OU Wen-chao, XIU Jian-cheng, XIE Jin-guo, ZHA Dao-gang, LIU Jian, HAO Rui, BIN Jian-ping, LIU Yi-li

第一军医大学南方医院心内科, 广东, 广州, 510515

Online:2004-05-20 Published:2004-05-20

摘要/Abstract

摘要： 目的探讨无溶栓药物条件下超声+微泡对血栓溶解的作用。方法建立12只兔双侧股动脉急性血栓模型,对其中6只经静脉注射白蛋白微泡,一侧动脉接受经皮超声(超声+微泡组)而另一侧接受无超声治疗(微泡组)。另外6只兔一侧动脉只接受超声治疗(超声组)而另一侧不接受任何处理(对照组)。结果单独超声治疗的6条动脉只有2条再通,接受超声+微泡治疗的6条动脉全部实现再通(P=0.014),微泡组和对照组动脉无再通。超声+微泡组动脉再通时间和残余血栓面积比值显著小于超声组(P=0.004,P=0.003 )。结论超声作用下经静脉注射微泡能有效促进在体动脉血栓溶解,这对临床急性血栓形成患者有潜在的应用意义。

Abstract: Objective To evaluate the efficacy of intravenous ultrasound microbubbles for thrombolysis of arterial thrombus without using thrombolytic drugs. Methods Twelve rabbit models of acute bilateral femoral artery thrombosis were established and 6 of them received transcutaneous ultrasound and intravenous albumin microbubble treatment for thrombosis on one side while only microbubble treatment for the other side. The other 6 rabbits received ultrasound treatment on one side but no treatment on the other to serve as the control group. Results None of the 6 arteries treated with microbubbles alone and only 2 arteries treated with ultrasound alone in the 6 control rabbits were recanalized. All the 6 femoral arteries treated with microbubbles together with ultrasound were recanalized (P=0.014), with significantly shorter patent time and smaller residual thrombus cross-sectional area than those of the arteries with only ultrasound treatment (P=0.004 and P=0.003, respectively). Conclusion Treatment with intravenous microbubbles assisted by transcutaneous ultrasound effectively promotes arterial thrombolysis in vivo, and this technique can be of significance in clinical treatment of acute thrombotic occlusions.

中图分类号:

区文超, 修建成, 谢晋国, 查道刚, 刘俭, 郝睿, 宾建平, 刘伊丽. 超声联合微泡对兔股动脉血栓的促溶作用[J]. 南方医科大学学报, 2004, 24(05): 536-538.

OU Wen-chao, XIU Jian-cheng, XIE Jin-guo, ZHA Dao-gang, LIU Jian, HAO Rui, BIN Jian-ping, LIU Yi-li. Ultrasound microbubbles promote thrombolysis of rabbit femoral artery thrombus[J]. Journal of Southern Medical University, 2004, 24(05): 536-538.

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