新疆和田地区维吾尔族、汉族人群Rh血型分布调查与比较

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (04): 447-449.

新疆和田地区维吾尔族、汉族人群Rh血型分布调查与比较

库热西江·托呼提¹, 哈木拉提·吾甫尔², 努尔买买提·伊力¹, 穆亚赛尔·库热西¹, 帕丽达·哈巴尔·如孜¹, 哈力克·伊米提¹, 美丽克·伊和帕¹, 张利占¹, 买买提阿布拉·艾沙¹

1. 新疆墨玉县人民医院, 新疆, 墨玉, 848100;
2. 新疆维吾尔医学研究所, 新疆, 乌鲁木齐, 830001

出版日期:2004-04-20 发布日期:2004-04-20
基金资助:
收稿日期:2003-7-12。
作者简介:库热西江.托呼提(1966-),男,主管检验师,现为人事部新疆少数民族青年科技人才特殊培养对象,委培在新疆维吾尔医学研究所分子生物学研究室从事血型遗传学和维吾尔医学基础研究,电话:0903-6515535(0991-8105351),E-mail:kuraxht@21cn.com

Comparative investigation of the Rh blood type distribution between the Uygur and Han nationalities in the Khotan area of Xinjiang Autonomous Region

Kurexijiang Tuohuti¹, Hamulati Wufuer², Nuermaimaiti Yili¹, Muyasaier Kurexi¹, Palida Habaer Ruzi¹, Halike Yimi-ti¹, Meilike Yihepa¹, ZHANG Li-zhan¹, Maimaitiabula Aisha¹

1. 新疆墨玉县人民医院, 新疆, 墨玉, 848100;
2. 新疆维吾尔医学研究所, 新疆, 乌鲁木齐, 830001

Online:2004-04-20 Published:2004-04-20

摘要/Abstract

摘要： 目的对和田维吾尔族和汉族人群的Rh血型分布进行调查并与既往的维吾尔族Rh血型调查资料进行比较分析。方法采用流行病学方法普查2 907人Rh血型,其中维吾尔族2251人、汉族656人。对ABO血型采用正定玻片法、Rh血型采用血清学盐水介质法测定,另外对RhD阴性个体检测Rh血型血清学表型。结果共检出106例RhD阴性个体,RhD阴性率为4.71%, D基因频率为0.217,其Rh表型除1例为ccdEe型外其余为ccdee型。维吾尔族RhD阴性个体的ABO血型与随机抽取维吾尔族个体的ABO血型的比较结果显示,RhD阴性个体中B型者偏高、而A、O型者偏低。结论维吾尔族的Rh血型的基因频率较高,且Rh表型具有特殊性。

Abstract: Objective To investigate the Rh blood type distribution in the Uygur and Han nationalities in Khotan area of Xin-jiang Autonomous Region, China, and compare the results with previous documentations on the Rh blood type in Uighurs. Method Using epidemiological methods, an extensive survey was conducted for determination of the Rh blood type in 2 907 residents in the target area, including 2 251 Uighurs and 656 subjects of Han nationality. Positive definition method was used for the ABO blood typing while Rh blood type was determined serologically through saline medium method. At the same time, the Rh phenotypes were investigated in RhD-negative individuals. Results Altogether 106 RhD-negative individuals were identified, accounting for a rate of 4.71% in this cohort, with the D gene frequency of 0.217. The Rh phenotype of all RhD- negative cases were ccdee except for one that was ccdEe. When compared with the previous ABO blood type distribution data of the Uighurs in randomly chosen samples, B type in RhD-negative individuals was relatively higher while A and O types peared lower. Conclusion The Rh blood type frequency is relatively higher in the Uighurs with unique Rh phenotypes.

中图分类号:

R446.11

库热西江·托呼提¹, 哈木拉提·吾甫尔², 努尔买买提·伊力¹, 穆亚赛尔·库热西¹, 帕丽达·哈巴尔·如孜¹, 哈力克·伊米提¹, 美丽克·伊和帕¹, 张利占¹, 买买提阿布拉·艾沙¹. 新疆和田地区维吾尔族、汉族人群Rh血型分布调查与比较[J]. 南方医科大学学报, 2004, 24(04): 447-449.

Kurexijiang Tuohuti¹, Hamulati Wufuer², Nuermaimaiti Yili¹, Muyasaier Kurexi¹, Palida Habaer Ruzi¹, Halike Yimi-ti¹, Meilike Yihepa¹, ZHANG Li-zhan¹, Maimaitiabula Aisha¹. Comparative investigation of the Rh blood type distribution between the Uygur and Han nationalities in the Khotan area of Xinjiang Autonomous Region[J]. Journal of Southern Medical University, 2004, 24(04): 447-449.

参考文献

[1] 赵桐茂.人类血型遗传学[M].北京:科学出版社,1987.101-6.
[2] 库热西江·托呼提,张利占,买买提江.新疆维吾尔族墨玉县维族普查人群和维族白内障患者的ABO血型调查[J].中国输血杂志(Chin JBloodTransfusion),2000,13(增刊):27.
[3] 袁义达,乌云艾,绍萱,等.新疆维吾尔族的红细胞血液型系统的研究[J].中华血液学杂志(Chin J Hemato1),1984,5(5):305.
[4] 血型调查组.我国十六个民族的血型调查报告:ⅢRh血型调查结果[J].中华血液学杂志(Chin J Hemato1),1981,2(4):209-11.
[5] 李树温,邹清孝.新疆喀什地区维吾尔族Rho,D抗原的分布[J].中华血液学杂志(Chin J Hemato1),1980,1(3):141.
[6] 刘惠宣,王拥军,赵宇红,等.13 422对夫妇ABO及Rh血型鉴定资料分析[J].新疆医学(Xinjiang Med),1998,28(3):164-5.
[7] 鲁爱军.2001年喀什地区献血者RhD阴性情况调查[J].中国输血杂志(Chin J Blood Transfusion),2003,16(2):86.
[8] 赵桐茂.Rh基因结构之谜[J].中国输血杂志(Chin J Blood Transfus),1998,11(4):216.
[9] 兰炯采,杨世英.妇女在第一胎人流时及生育前输血时Rh定性的重要性[J].中华血液学杂志(Chin J Hematol),1989,10(4):188-9.
[10] kuda H, Kawano M, lwarnoto S, et al. The RHD gene is highly detectable in RhD-negative Japanese donors[J]. J Clin Invest, 1997,100(2): 373-9.
[11] Lan JC, Chen Q, Wu DL, et al. Genetic polymorphism of Rh Dnegative associated haplotypes in the Chinese[J]. J Human Genet,2000, 45(4): 224-7.
[12] 徐群,张世训,张建业,等.中国汉族群体RhD(-)个体RHD基因和CE基因外显子多态性研究[J].中华医学遗传学杂志,2001,18(1):39-41.Xu Q, Zhang SX, Zhang JY, et al. Study on polymorphism of D gene exens among RhD-negative Chinese population[J]. Chin J Med Genet, 2001,18(1): 39-41.
[13] 吴钟玲,刘富昌,徐晶,等.南昌地区ABO血型与RH血型调查[J].江西医学检验杂志(Jiangxi Med Lab Sci),2001,19(2):115.