对氧磷酶1基因Gln192Arg多态性与阿尔茨海默病的关联研究

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (04): 371-374.

对氧磷酶1基因Gln192Arg多态性与阿尔茨海默病的关联研究

施佳军^1,2, 张思仲¹, 马崔², 唐牟尼², 刘协和³, 王英成³, 韩海英², 郭扬波², 冯容妹², 苗国栋²

1. 四川大学华西医院医学遗传室, 教育部人类疾病生物治疗重点实验室人类疾病基因组学研究室, 四川, 成都, 610041;
2. 广州市精神病医院, 广东, 广州, 510370;
3. 四川大学华西医院心理卫生中心, 四川, 成都, 610041

出版日期:2004-04-20 发布日期:2004-04-20
基金资助:
收稿日期:2003-12-8。
基金项目:国家自然科学基金重大项目(39993420);国家高技术研究发展计划(863计划)(2001AA224021-03);广州市科技攻关重大项目(JB(02)2000-2-026-01)
作者简介:施佳军(1969-),男,1993年毕业于湖南师范大学,医学遗传学博士生,电话:028-85422749,E-mail:shiand98@21cn.com

Gln192Arg polymorphism of the paraoxonase-1gene is not associated with Alzheimer’s disease in Chinese

SHI Jia-jun^1,2, ZHANG Si-zhong¹, MA Cui², TANG Mou-ni², LIU Xie-he³, WANG Ying-cheng³, HAN Hai-ying², GUO Yang-bo², FENG Rong-mei², MIAO Guo-dong²

1. 四川大学华西医院医学遗传室, 教育部人类疾病生物治疗重点实验室人类疾病基因组学研究室, 四川, 成都, 610041;
2. 广州市精神病医院, 广东, 广州, 510370;
3. 四川大学华西医院心理卫生中心, 四川, 成都, 610041

Online:2004-04-20 Published:2004-04-20

摘要/Abstract

摘要： 目的探讨对氧磷酶1(paraoxonase-1, PON1)基因Gln192Arg多态性与汉族散发阿尔茨海默病(AD)的关系。方法以165例散发AD患者和174例年龄匹配老年人为对象进行病例-对照研究。用PCR-RFLP法检测PON1及载脂蛋白E(ApoE)基因多态并进行关联分析。结果 AD组与对照组PON1 基因Gln192Arg多态性分布没有显著性差异。研究对象按ApoEε4携带状况分层后,各亚组之间基因多态性分布亦无显著性差异。结论 PON1基因Gln192Arg多态性与中国汉族人群AD不存在关联。

Abstract: Objective To explore the relationship between paraoxonase-1 (PON1) gene Gln192Arg polymorphism and sporadic Alzheimer’s disease (AD) in Chinese. Methods A total of 165 AD patients and 174 age-matched control subjects were enrolled in this study for examination of PON1 Gln192Arg and apolipoprotein E gene polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The distribution of PON1 allelic and genotypic frequencies did not significantly differ between AD patients and the control subjects, even after the stratification by ApoE-epsilon4 status. Conclusion Gln192Arg polymorphism of the PON1 gene is not associated with sporadic AD in Chinese.

中图分类号:

R596
Q78

施佳军^1,2, 张思仲¹, 马崔², 唐牟尼², 刘协和³, 王英成³, 韩海英², 郭扬波², 冯容妹², 苗国栋². 对氧磷酶1基因Gln192Arg多态性与阿尔茨海默病的关联研究[J]. 南方医科大学学报, 2004, 24(04): 371-374.

SHI Jia-jun^1,2, ZHANG Si-zhong¹, MA Cui², TANG Mou-ni², LIU Xie-he³, WANG Ying-cheng³, HAN Hai-ying², GUO Yang-bo², FENG Rong-mei², MIAO Guo-dong². Gln192Arg polymorphism of the paraoxonase-1gene is not associated with Alzheimer’s disease in Chinese[J]. Journal of Southern Medical University, 2004, 24(04): 371-374.

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