冠心病患者血清中肺炎衣原体免疫复合物及抗体检测的临床分析

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (04): 365-366,391.

冠心病患者血清中肺炎衣原体免疫复合物及抗体检测的临床分析

孙芸芸¹, 蒋文玲², 罗宪玲², 陈纪言¹

1. 广东省老年医学研究所, 广东, 广州, 510080;
2. 广东省心血管病研究所, 广东, 广州, 510100

出版日期:2004-04-20 发布日期:2004-04-20
基金资助:
基金项目:This study is sponsored by the Department of Science and Technology of Guangdong Province (99M04608)
作者简介:SUN Yun-yun(1952),Associate Professor,Attending Physician,Tel:020-83827812-41241,E-mail:sunyunyun54321@sina.com

Detection of serum Chlamydia pneumoniae(Cpn)immune complex and Cpn antibody in patients with coronary heart disease

SUN Yun-yun¹, JIANG Wen-ling², LUO Xian-ling², CHEN Ji-yan¹

1. 广东省老年医学研究所, 广东, 广州, 510080;
2. 广东省心血管病研究所, 广东, 广州, 510100

Online:2004-04-20 Published:2004-04-20

摘要/Abstract

摘要： 目的了解冠心病患者肺炎衣原体感染状况,探讨肺炎衣原体(Cpn)感染与冠心病的发生发展关系。方法采用双抗体夹心法、间接ELISA法检测了160例经冠状动脉造影证实的冠心病患者和40例非冠心病患者血清中肺炎衣原体免疫复合物(CPn CIC)和IgG抗体。结果冠心病组Cpn IgG型免疫复合物的阳性率(63.8%)高于对照组(40.0%, P<0.05)。CPn IgG抗体阳性率冠心病组为65.0%对照组为32.5%,前者阳性率显著同于后者(P<0.05)。结论 Cpn感染与冠心病关系密切,但尚需进一步深入探讨。

Abstract: Objective To understand the state of Chlamydia pneumoniae(Cpn) infection in patients with coronary heart dis-ease (CHD), and explore the relationship between Cpn infection and the gonesis and progressin of CHD. Method By adopt-ing sandwich method with double antibodies and indirect ELISA method, we detected serum Cpn immune complex and IgG antibody in 160 CHD patients (confirmed by coronary artery angiography) and 40 subjects without CHD. Results The posi-tivity rate of Cpn IgG type immune complex in the CHD group (63.8%) was significantly higher than that in the control group (40.0%, P<0.05), similar to the results of Cpn IgG antibody detection (65.0% vs32.5%, P<0.05). Conclusion Cpn infection is closely connected with the CHD, but their exact relationship needs further exploration and study.

中图分类号:

孙芸芸¹, 蒋文玲², 罗宪玲², 陈纪言¹. 冠心病患者血清中肺炎衣原体免疫复合物及抗体检测的临床分析[J]. 南方医科大学学报, 2004, 24(04): 365-366,391.

SUN Yun-yun¹, JIANG Wen-ling², LUO Xian-ling², CHEN Ji-yan¹. Detection of serum Chlamydia pneumoniae(Cpn)immune complex and Cpn antibody in patients with coronary heart disease[J]. Journal of Southern Medical University, 2004, 24(04): 365-366,391.

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