南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (02): 234-235.

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血液净化对慢性肾功能衰竭患者全段甲状旁腺激素的影响

刘俊, 刘志强, 陶惠琴   

  1. 第一军医大学南方医院肾内科, 广东, 广州, 510515
  • 出版日期:2004-02-20 发布日期:2004-02-20
  • 基金资助:
    收稿日期:2003-5-11。
    作者简介:刘俊(1962-),男,山东龙口人,1985年毕业于第一军医大学,硕士,副教授,副主任医师,电话:020-61641598

Effect of blood purification on plasma levels of intact parathyroid hormone in patients with chronic renal failure

LIU Jun, LIU Zhi-qiang, TAO Hui-qin   

  1. 第一军医大学南方医院肾内科, 广东, 广州, 510515
  • Online:2004-02-20 Published:2004-02-20

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摘要： 目的 研究血液灌流和/或血液透析对慢性肾功能衰竭(CRF)患者全段甲状旁腺激素(iPTH)的影响。方法 用放射免疫测定法检测40例规律血液透析患者治疗前后iPTH水平。结果 血液灌流和/或血液透析后iPTH水平均降低,但血液灌流组降低幅度大于血液透析组(P=0.031)。结论 血液灌流加血液透析能比单纯血液透析更有效地降低CRF患者iPTH水平。

Abstract: Objective To study the effects of hemoperfusion and/or hemodialysis on plasma levels of intact parathyroid hormone (iPTH) in patients with chronic renal failure (CRF). Methods A total of 40 uremic patients were randomly divided into two groups to receive hemoperfusion in combination with hemodialysis (HP+HD) or exclusive hemodialysis (HD), respectively. Plasma iPTH concentration was measured by means of radio immunoassay. Results After the blood purification procedures, the patients’ plasma iPTH levels were reduced from 1 508.70±1 268.89 to 1 049.04±992.91 μg/ml (P<0.001) in HD group and from 1 600.70±1 151.15 to 745.47±785.02 μg/ml (P<0.001) in HP+HD group. Conclusion Blood purification with hemoperfusion plus hemodialysis may decrease plasma iPTH levels more efficiently than hemodialysis performed alone.

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