聚氰基丙烯酸正丁酯磁性纳米球的制备与表征

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (02): 161-163,167.

聚氰基丙烯酸正丁酯磁性纳米球的制备与表征

任非¹, 陈建海¹, 姜耀东², 陈志良¹

1. 第一军医大学南方医院药学部, 广东, 广州, 510515;
2. 第一军医大学南方医院泌尿外科, 广东, 广州, 510515

出版日期:2004-02-20 发布日期:2004-02-20
基金资助:
收稿日期:2003-10-10。
基金项目:国家863项目(2002AA₂14121);广东省科技攻关项目(2002C30103)
作者简介:任非(1974-),女,陕西西安人,第一军医大学在读博士研究生,电话:020-61641888-87236,E-mail:renfeisky@163.net

Preparation and characterization of polybutylcyanoacrylate magnetic nanoparticles

REN Fei¹, CHEN Jian-hai¹, JIANG Yao-dong², CHEN Zhi-liang¹

1. 第一军医大学南方医院药学部, 广东, 广州, 510515;
2. 第一军医大学南方医院泌尿外科, 广东, 广州, 510515

Online:2004-02-20 Published:2004-02-20

摘要/Abstract

摘要： 目的制备聚氰基丙烯酸正丁酯(PBCA)磁性纳米球。方法乳化聚合法制备磁性纳米球的悬浮液,光子相关光谱仪和透射电镜测定磁性纳米球的粒径及其分布;紫外分光光度法测定磁性纳米球中Fe含量。结果获得了水溶性正癸酸稳定的Fe₃O₄磁流体的粒径及其分布,以及载体浓度与稳定剂浓度对磁性纳米球粒径及其分布的影响。结论首次在pH=6.3~6.4条件下用乳化聚合法制备了PBCA磁性纳米球的稳定悬浮液。

Abstract: Objective To Prepare and characterize polybutylcyanoacrylate (PBCA) magnetic nanoparticles.Methods The suspension of PBCA magnetic nanoparticles was prepared by emulsion polymerization method. The particle size, size distri-bution, polydispersity and other parameters were determined by photon correlation spectroscopy and transmission electron microscopy, and the iron content in the nanoparticles by ultraviolet spectroscopy. Results The data of the particle size and size distribution of aqueous decanoic acid stabilized Fe₃O₄ magnetic fluids were acquired, and the influences of concentrations of butylcyanoacrylate (BCA) and Dextran-70 on the particle size and size distribution of PBCA magnetic nanoparticles were characterized. Conclusion We have for the first time successfully prepared stable suspension of PBCA magnetic nanoparti-cles by emulsion polymerization method at pH 6.3-6.4 in aqueous medium.

中图分类号:

R977.6

任非¹, 陈建海¹, 姜耀东², 陈志良¹. 聚氰基丙烯酸正丁酯磁性纳米球的制备与表征[J]. 南方医科大学学报, 2004, 24(02): 161-163,167.

REN Fei¹, CHEN Jian-hai¹, JIANG Yao-dong², CHEN Zhi-liang¹. Preparation and characterization of polybutylcyanoacrylate magnetic nanoparticles[J]. Journal of Southern Medical University, 2004, 24(02): 161-163,167.

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