肝脾γδT细胞淋巴瘤的临床病理学观察

摘要/Abstract

摘要： 目的探讨肝脾γδT细胞淋巴瘤的临床病理学特征和免疫表型。方法应用常规病理、免疫组化观察1例肝脾γδT细胞淋巴瘤并对相关文献进行调研。结果患者肝脾明显增大,镜下显示瘤细胞弥漫浸润脾脏红髓血窦,瘤细胞中等大,胞浆淡染,核染色质较细腻,核仁不明显。肝脏血窦内瘤细胞呈佛珠状或线样浸润,免疫表型:瘤细胞表达CD45RO、CD3和TIA-1,而CD57、CD20和CD79a等标记阴性。结论肝脾γδT细胞淋巴瘤是较为罕见的外周T细胞淋巴瘤,预后较差,应注意与其他淋巴瘤和白血病的鉴别。

Abstract: Objective To explore the clinicopathologic features and immunophenotype of hepatosplenicγδT-cell lymphoma.Methods A case of hepatosplenic γδT-cell lymphoma was stud ied with conventional histopathological and immunohisto-chemical staining in com bination of literature review.Results Diffuse hepatic and splenic enlargement w as found in this case. Microscopically, the liver and spleen showed marked sinu soidal infiltration. The cells of hepatosplenic T-cell lymphoma were homogeneou s, medium in size with pale cytoplasm, and the nuclear chromatin was loosely con densed with small inconspicu-ous nucleoli. The neoplastic cells were positive fo r CD45RO, CD3 and TIA-1, but negative for CD57, CD20 and CD79a.Conclusion Hepa tosplenic γδT-cell lymphoma is a rare form of peripheral T-cell lymphoma and h as usually poor prognosis, which should be differentiated from other lymphomas or leukemia.

中图分类号:

R733

耿舰, 朱梅刚, 丁彦青, 韩慧霞. 肝脾γδT细胞淋巴瘤的临床病理学观察[J]. 南方医科大学学报, 2004, 24(01): 88-90.

GENG Jian, ZHU Mei-gang, DING Yan-qing, HAN Hui-xia. HepatosplenicγδT-cell lymphoma:a clinicopathological study[J]. Journal of Southern Medical University, 2004, 24(01): 88-90.

参考文献

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