人脑胶质瘤与人脑转移瘤中NF-κBP65的表达及意义

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (01): 75-78.

人脑胶质瘤与人脑转移瘤中NF-κBP65的表达及意义

唐万忠¹, 夏玉军²

1. 青岛大学医学院附属医院创伤外科, 山东, 青岛, 266003;
2. 青岛大学医学院人体解剖学教研室, 山东, 青岛, 266021

出版日期:2004-01-20 发布日期:2004-01-20
基金资助:
收稿日期:2003-11-25。
基金项目:山东省教委基金(99k53)
作者简介:唐万忠(1969- ),男,2003年毕业于青岛大学医学院,硕士,主治医师,电话:0532-2911276

Expression of nuclear factor-κBP65in human brain glioma and human brain metastatic car-cinoma and its significance

TANG Wan-zhong¹, XIA Yu-Jun²

1. 青岛大学医学院附属医院创伤外科, 山东, 青岛, 266003;
2. 青岛大学医学院人体解剖学教研室, 山东, 青岛, 266021

Online:2004-01-20 Published:2004-01-20

摘要/Abstract

摘要： 目的研究人脑胶质瘤(HBG)与人脑转移瘤(HBMC)中核转录因子κBP65(NF-κBP65)的表达及其在肿瘤生物学行为中的作用。方法应用SABC方法进行免疫组织化学染色,观察6例正常人脑组织、18例HBG组织与12例HBMC组织中NF-κBP65的表达及与肿瘤生物学行为之间的关系。结果正常脑细胞中NF-κBP65仅微量表达,在HBG细胞与HBMC细胞中呈不同程度的表达;在高级别HBG、HBMC和复发型HBG中,表达水平较低级别HBG细胞的高(P<0.01)。结论 NF-κBP65表达的增强与HBG和HBMC恶性程度的增高、肿瘤浸润关系密切,并在HBG的复发中起重要作用。

Abstract: Objective To study the immunohistochemical changes of nuclear f actor-κBP65 (NF-κBp65) in human brain glioma (HBG) and human brain metastatic carcinoma (HBMC) and the role of NF-κBP65 in the biological behavior of the tu -mors.Methods The protein expression of NF-κBP65 were examined with SABC immun ohistochemical technique in 18 HBG, 12 HBMC and 6 normal brain tissue samples, and the correlation between the expression and the biological behavior of the t umors was analyzed.Results Normal brain tissues had only trace expression of NF -κBP65, whereas all tumor tissues ex-amined expressed NF-κBP65. The level of N F-κBP65 in high-grade HBG, HBMC and recurrent HBG tissues was consider-ably hig her than that in low-grade HBG tissues (P<0.01).Conclusion NF-κBP65 expression is associated with the malignant progression, invasion and angiogenesis of HBG and HBMC, and it may play a crucial role in the recurrence of HBG.

中图分类号:

R739.41

唐万忠¹, 夏玉军². 人脑胶质瘤与人脑转移瘤中NF-κBP65的表达及意义[J]. 南方医科大学学报, 2004, 24(01): 75-78.

TANG Wan-zhong¹, XIA Yu-Jun². Expression of nuclear factor-κBP65in human brain glioma and human brain metastatic car-cinoma and its significance[J]. Journal of Southern Medical University, 2004, 24(01): 75-78.

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