南方医科大学学报

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (01): 57-58.

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黄芪水煎液抗Ⅰ型单纯疱疹病毒的实验研究

孙艳, 杨洁   

  1. 解放军总医院药材处, 北京, 100853
  • 出版日期:2004-01-20 发布日期:2004-01-20
  • 基金资助:
    收稿日期:2003-9-22。
    作者简介:孙艳(1963- ),女,第一军医大学毕业,本科,主管药师,电话:010-66939446

Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type1

SUN Yan, YANG Jie   

  1. 解放军总医院药材处, 北京, 100853
  • Online:2004-01-20 Published:2004-01-20

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摘要： 目的 研究黄芪抗Ⅰ型单纯疱疹病毒(HSV-Ⅰ)的作用。方法 在人胚肺二倍体细胞系统中,采用对病毒所致细胞病变的抑制实验,观察黄芪水煎液抗HSV-I的药效。结果 黄芪水煎液的半数抑制浓度为0.98µg/ml,最小有效浓度为1.95µg/ml,治疗指数为128。结论 黄芪有较显著的抗HSV-Ⅰ作用,且对细胞毒性低。

Abstract: Objective To study the inhibitory eff ec ts of Astragalus membranaceus on herpes simplex virus type 1(HSV-1).Methods In the 2BS cells infected with HSV-1, the antiviral effect of Astragalus membranac eus decoction was investigated by observing the inhibition of HSV-1-induced cyt opathic effect in response to treatment with the decoction.Results The half in hibition concentration (IC50) and minimal inhibition concentration (MIC) of Astr agalus membranaceus were 0.98 and 1.95µg/ml respectively, with the therapeutic index (TI) of 128.Conclusion Astragalus membranaceus has obvious HSV-1-inhibit -ing efficacy and low cytotoxicity.

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