表皮生长因子受体介导的PLC-g1水解PIP2的数学建模

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (01): 18-20,23.

表皮生长因子受体介导的PLC-g1水解PIP₂的数学建模

苏永春¹, 邓凡², 陆地², 白晓春², 谭小丹¹, 董爱荣¹, 罗深秋², 邓亲恺¹

1. 第一军医大学, 医学物理学教研室, 广东, 广州, 510515;
2. 第一军医大学, 细胞生物学教研室, 广东, 广州, 510515

出版日期:2004-01-20 发布日期:2004-01-20
基金资助:
收稿日期:2003-5-23。
基金项目:国家自然科学基金(39870381);广东省自然科学基金(020015);军队医学卫生科研基金(01MB098)
作者简介:苏永春(1972- ),男,第一军医大学在读博士研究生,电话:020-61365584,E-mail:suyc@fimmu.com
通讯作者:邓亲恺,电话:020-61648279;罗深秋,电话:020-61648208

Mathematical model of epidermal growth factor receptor-mediated lipid phosph atidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1activity

SU Yong-chun¹, DENG Fan², LU Di², BAI Xiao-chun², TAN Xiao-dan¹, DONG Ai-rong¹, LUO Shen-qiu², DENG Qin-kai¹

1. 第一军医大学, 医学物理学教研室, 广东, 广州, 510515;
2. 第一军医大学, 细胞生物学教研室, 广东, 广州, 510515

Online:2004-01-20 Published:2004-01-20

摘要/Abstract

摘要： 目的探讨表皮生长因子刺激下磷脂酶C-g1(PLC-g1)水解细胞膜上PIP₂(PIP₂)的动力学特性。方法根据质量作用定律,利用微分方程对PIP₂的代谢途径进行数学建模。结果建立了PIP₂水解过程中关键产物浓度的微分方程,分析了各个参数对这些水解产物的影响。结论这个数学模型为进一步描述PIP₂代谢循环的生物学特征和主要产物间浓度依赖关系的动态变化奠定了基础。

Abstract: Objective To investigate the dynamic characteristics of lipid phosphatidylinositol (4,5)-bisphosphate (PIP₂) in plasma membrane hydrolyzed by phospholipase C-gamma1 in epidermal grow th factor receptor(EGFR)-mediated signal path-way.Methods A mathematical model based on the law of mass action was established with differential equations to s imulate metabolizable pathway of PIP₂.Results Differential equations of the key product concentration during hyd rolysis of PIP₂ were formulated, and the effects of the parameters on these hydrolyzed pro ducts analyzed.Conclusion This mathematical model provides foundation for furt her investigation of the dynamic changes of biological characteristics and the r elations between the key product concentrations in PIP₂ hydrolysis.

中图分类号:

苏永春¹, 邓凡², 陆地², 白晓春², 谭小丹¹, 董爱荣¹, 罗深秋², 邓亲恺¹. 表皮生长因子受体介导的PLC-g1水解PIP₂的数学建模[J]. 南方医科大学学报, 2004, 24(01): 18-20,23.

SU Yong-chun¹, DENG Fan², LU Di², BAI Xiao-chun², TAN Xiao-dan¹, DONG Ai-rong¹, LUO Shen-qiu², DENG Qin-kai¹. Mathematical model of epidermal growth factor receptor-mediated lipid phosph atidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1activity[J]. Journal of Southern Medical University, 2004, 24(01): 18-20,23.

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表皮生长因子受体介导的PLC-g1水解PIP₂的数学建模

Mathematical model of epidermal growth factor receptor-mediated lipid phosph atidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1activity

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