重症蛛网膜下腔出血患者入院早期平均动脉压变异性与院内死亡风险的U形关系：基于MIMIC-IV和eICU-CRD数据库

doi:10.12122/j.issn.1673-4254.2026.08.05

南方医科大学学报 ›› 2026, Vol. 46 ›› Issue (8): 1764-1778.doi: 10.12122/j.issn.1673-4254.2026.08.05

重症蛛网膜下腔出血患者入院早期平均动脉压变异性与院内死亡风险的U形关系：基于MIMIC-IV和eICU-CRD数据库

向海艳¹^,²(), 陈秀娟³, 王来友¹^,², 赖伟华¹^,²()

^1.华南理工大学医学院，广东广州 510006；
^2.南方医科大学附属广东省人民医院（广东省医学科学院）临床药学科
^3.南方医科大学附属广东省人民医院（广东省医学科学院）医学大数据中心，广东广州 510080

收稿日期:2025-12-24 出版日期:2026-08-20 发布日期:2026-08-01
通讯作者: 赖伟华 E-mail:x3143026490@outlook.com;laiweihuax@163.com
作者简介:向海艳，在读硕士研究生，E-mail: x3143026490@outlook.com
基金资助:
国家自然科学基金(82274120);广东省基础与应用基础研究基金(2023A1515010405);广东省人民医院引进高层次全职人才科研经费(KY012021198);广东省人民医院院内项目(2023-08)

Early mean arterial pressure variability and in-hospital mortality from severe subarachnoid hemorrhage: a U-shaped association based on MIMIC-IV and eICU-CRD data

Haiyan XIANG¹^,²(), Xiujuan CHEN³, Laiyou WANG¹^,², Weihua LAI¹^,²()

^1.School of Medicine, South China University of Technology, Guangzhou 510006, China
^2.Department of Clinical Pharmacy，Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China
^3.Medical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China

Received:2025-12-24 Online:2026-08-20 Published:2026-08-01
Contact: Weihua LAI E-mail:x3143026490@outlook.com;laiweihuax@163.com
Supported by:
National Natural Science Foundation of China(82274120)

摘要/Abstract

摘要：

目的探讨非创伤性蛛网膜下腔出血（NSAH）患者入院早期平均动脉压变异性（MBPV）与院内死亡的关联。方法基于重症监护医学信息数据库Ⅳ版（MIMIC-Ⅳ）与电子重症监护病房协作研究数据库（eICU-CRD），纳入1345~1820例NSAH患者。提取入院24、48、72 h平均动脉压（MBP）数据，计算标准差（SD）、平均真实变异性（ARV）、极差（Range）、连续变异（SV）作为MBPV指标。采用限制性立方样条（RCS）结合Cox回归分析非线性关系，分段回归确定风险拐点；对违反比例风险假设的指标进行时依Cox回归；并通过排除72 h内手术者、药物信息缺失者两项敏感性分析验证结果稳健性。结果各时间窗MBPV均与院内死亡呈显著U型非线性关联（均P<0.05），过低或过高波动均升高死亡风险，其中入院24 h关联最强、稳定性最优。时依分析显示，ARV、SV的风险效应在入院4~7 d后更显著，SD、Range的风险效应则主要集中于入院前14 d。综合稳定性分析显示，24 h和72 h的MBPV为关联最稳健的指标。两项敏感性分析结果与主分析一致。结论 NSAH患者早期MBPV与院内死亡呈U型关联，中等波动提示更佳预后；24 h的MBPV可作为早期血压监测的首选指标。

关键词: 非创伤性蛛网膜下腔出血, 院内死亡, 平均动脉压变异性, ICU患者, 非线性

Abstract:

Objective To explore the association between mean arterial pressure variability (MBPV) and in-hospital mortality in patients with non-traumatic subarachnoid hemorrhage (NSAH). Methods This study was conducted using the data of NSAH patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and the eICU-CRD, with the final sample size ranging from 1345 to 1820 subjects across different MBPV indicators. Mean arterial pressure (MAP) data within 24, 48, and 72 h after admission were extracted, and the standard deviation (SD), average real variability (ARV), range, and successive variability (SV) of MBPV were calculated. Restricted cubic spline (RCS) combined with Cox regression analysis was adopted to evaluate the nonlinear correlation and determine the risk inflection point using piecewise regression. Time-dependent Cox regression was performed only for variables violating the proportional hazards assumption. Two sensitivity analyses were conducted (excluding patients with surgery within 72 h of admission and those with missing data of medication) to validate the robustness of the results. The primary outcome was all-cause in-hospital mortality. Results MBPV at all time windows showed a U-shaped nonlinear association with in-hospital mortality of the patients (all P<0.05), and the strongest association was found at 24 h. The inflection point of MBP SD was 8.9, and either excessively low or high fluctuation increased the mortality risk. Time-dependent analysis showed that ARV and SV of MBPV became more hazardous after 4-7 days, while its SD and range were risky mainly within the first 14 days. Both sensitivity analyses confirmed the robustness of the main results. Conclusion Early MBPV presents a U-shaped association with in-hospital mortality from NSAH, and moderate fluctuation predicts better prognosis. MBP SDs within 24 and 72 h are the most robust indicators, and the former can serve as the preferred indicator for early blood pressure monitoring.

Key words: non-traumatic subarachnoid hemorrhage, in-hospital mortality, mean arterial pressure variability, ICU patients, nonlinearity

向海艳, 陈秀娟, 王来友, 赖伟华. 重症蛛网膜下腔出血患者入院早期平均动脉压变异性与院内死亡风险的U形关系：基于MIMIC-IV和eICU-CRD数据库[J]. 南方医科大学学报, 2026, 46(8): 1764-1778.

Haiyan XIANG, Xiujuan CHEN, Laiyou WANG, Weihua LAI. Early mean arterial pressure variability and in-hospital mortality from severe subarachnoid hemorrhage: a U-shaped association based on MIMIC-IV and eICU-CRD data[J]. Journal of Southern Medical University, 2026, 46(8): 1764-1778.

图/表 12

参考文献 28

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Variable	Total (n=1820)	Survival (n=1493)	Death (n=327)	P
Age [year, Median (IQR)]	60.3 (50.0, 71.9)	59.1 (49.5, 70.4)	66.0 (54.8, 78.9)	<0.001
Gender [n (%)]				0.338
Female	1045 (57.4)	865 (57.9)	180 (55)
Male	775 (42.6)	628 (42.1)	147 (45)
Race [n (%)]				<0.001
White	1173 (64.5)	994 (66.6)	179 (54.7)
Asian	56 (3.1)	42 (2.8)	14 (4.3)
Black	149 (8.2)	130 (8.7)	19 (5.8)
Other	442 (24.3)	327 (21.9)	115 (35.2)
Clinical scores
GCS [Median (IQR)]	14.0 (7.0, 15.0)	14.0 (9.0, 15.0)	6.0 (3.0, 10.0)	<0.001
SAPS Ⅱ [Median (IQR)]	27.0 (20.0, 38.0)	26.0 (18.0, 34.0)	39.0 (32.0, 49.0)	<0.001
PAASH scale [n (%)]				<0.001
I	725 (42.0)	696 (48.8)	29 (9.6)
II	348 (20.1)	310 (21.8)	38 (12.5)
III	185 (10.7)	150 (10.5)	35 (11.6)
IV	278 (16.1)	172 (12.1)	106 (35)
V	192 (11.1)	97 (6.8)	95 (31.4)
Comorbidities and personal history [n (%)]
Stroke history	106 (5.8)	85 (5.7)	21 (6.4)	0.61
Hypertension	807 (44.3)	660 (44.2)	147 (45)	0.805
Diabetes	180 (9.9)	136 (9.1)	44 (13.5)	0.017
Pneumonia	39 (5.9)	29 (5.2)	10 (9.4)	0.092
Epilepsy	42 (6.4)	31 (5.6)	11 (10.4)	0.064
Interventions after admission [n (%)]
Clipping within 24 h	68 (3.7)	59 (4)	9 (2.8)	0.3
Clipping within 48 h	76 (4.2)	67 (4.5)	9 (2.8)	0.155
Clipping within 72 h	79 (4.3)	70 (4.7)	9 (2.8)	0.12
Endovascular intervention within 24 h	420 (23.1)	373 (25)	47 (14.4)	<0.001
Endovascular intervention within 48 h	448 (24.6)	398 (26.7)	50 (15.3)	<0.001
Endovascular intervention within 72 h	458 (25.2)	408 (27.3)	50 (15.3)	<0.001
Mechanical ventilation within 24 h	764 (39.4)	475 (30.4)	289 (77.5)	<0.001
Mechanical ventilation within 48 h	786 (40.6)	493 (31.5)	293 (78.6)	<0.001
Mechanical ventilation within 72 h	801 (41.4)	503 (32.2)	298 (79.9)	<0.001
Antihypertensive within 24 h	687 (35.5)	558 (35.7)	129 (34.6)	0.692
Antihypertensive within 48 h	774 (40.0)	623 (39.8)	151 (40.5)	0.818
Antihypertensive within 72 h	831 (42.9)	669 (42.8)	162 (43.4)	0.818
Nimodipine within 24 h	360 (24.3)	328 (27.2)	32 (11.8)	<0.001
Nimodipine within 48 h	401 (27.1)	365 (30.2)	36 (13.2)	<0.001
Nimodipine within 72 h	426 (28.8)	388 (32.1)	38 (14)	<0.001
Sedatives within 24 h	538 (36.4)	406 (33.6)	132 (48.5)	<0.001
Sedatives within 48 h	614 (41.5)	464 (38.4)	150 (55.1)	<0.001
Sedatives within 72 h	661 (44.7)	500 (41.4)	161 (59.2)	<0.001
Vasopressors within 24 h	150 (10.1)	92 (7.6)	58 (21.3)	<0.001
Vasopressors within 48 h	185 (12.5)	118 (9.8)	67 (24.6)	<0.001
Vasopressors within 72 h	209 (14.1)	131 (10.8)	78 (28.7)	<0.001

Variable	Total (n=1820)	Survival (n=1493)	Death (n=327)	P
Age [year, Median (IQR)]	60.3 (50.0, 71.9)	59.1 (49.5, 70.4)	66.0 (54.8, 78.9)	<0.001
Gender [n (%)]				0.338
Female	1045 (57.4)	865 (57.9)	180 (55)
Male	775 (42.6)	628 (42.1)	147 (45)
Race [n (%)]				<0.001
White	1173 (64.5)	994 (66.6)	179 (54.7)
Asian	56 (3.1)	42 (2.8)	14 (4.3)
Black	149 (8.2)	130 (8.7)	19 (5.8)
Other	442 (24.3)	327 (21.9)	115 (35.2)
Clinical scores
GCS [Median (IQR)]	14.0 (7.0, 15.0)	14.0 (9.0, 15.0)	6.0 (3.0, 10.0)	<0.001
SAPS Ⅱ [Median (IQR)]	27.0 (20.0, 38.0)	26.0 (18.0, 34.0)	39.0 (32.0, 49.0)	<0.001
PAASH scale [n (%)]				<0.001
I	725 (42.0)	696 (48.8)	29 (9.6)
II	348 (20.1)	310 (21.8)	38 (12.5)
III	185 (10.7)	150 (10.5)	35 (11.6)
IV	278 (16.1)	172 (12.1)	106 (35)
V	192 (11.1)	97 (6.8)	95 (31.4)
Comorbidities and personal history [n (%)]
Stroke history	106 (5.8)	85 (5.7)	21 (6.4)	0.61
Hypertension	807 (44.3)	660 (44.2)	147 (45)	0.805
Diabetes	180 (9.9)	136 (9.1)	44 (13.5)	0.017
Pneumonia	39 (5.9)	29 (5.2)	10 (9.4)	0.092
Epilepsy	42 (6.4)	31 (5.6)	11 (10.4)	0.064
Interventions after admission [n (%)]
Clipping within 24 h	68 (3.7)	59 (4)	9 (2.8)	0.3
Clipping within 48 h	76 (4.2)	67 (4.5)	9 (2.8)	0.155
Clipping within 72 h	79 (4.3)	70 (4.7)	9 (2.8)	0.12
Endovascular intervention within 24 h	420 (23.1)	373 (25)	47 (14.4)	<0.001
Endovascular intervention within 48 h	448 (24.6)	398 (26.7)	50 (15.3)	<0.001
Endovascular intervention within 72 h	458 (25.2)	408 (27.3)	50 (15.3)	<0.001
Mechanical ventilation within 24 h	764 (39.4)	475 (30.4)	289 (77.5)	<0.001
Mechanical ventilation within 48 h	786 (40.6)	493 (31.5)	293 (78.6)	<0.001
Mechanical ventilation within 72 h	801 (41.4)	503 (32.2)	298 (79.9)	<0.001
Antihypertensive within 24 h	687 (35.5)	558 (35.7)	129 (34.6)	0.692
Antihypertensive within 48 h	774 (40.0)	623 (39.8)	151 (40.5)	0.818
Antihypertensive within 72 h	831 (42.9)	669 (42.8)	162 (43.4)	0.818
Nimodipine within 24 h	360 (24.3)	328 (27.2)	32 (11.8)	<0.001
Nimodipine within 48 h	401 (27.1)	365 (30.2)	36 (13.2)	<0.001
Nimodipine within 72 h	426 (28.8)	388 (32.1)	38 (14)	<0.001
Sedatives within 24 h	538 (36.4)	406 (33.6)	132 (48.5)	<0.001
Sedatives within 48 h	614 (41.5)	464 (38.4)	150 (55.1)	<0.001
Sedatives within 72 h	661 (44.7)	500 (41.4)	161 (59.2)	<0.001
Vasopressors within 24 h	150 (10.1)	92 (7.6)	58 (21.3)	<0.001
Vasopressors within 48 h	185 (12.5)	118 (9.8)	67 (24.6)	<0.001
Vasopressors within 72 h	209 (14.1)	131 (10.8)	78 (28.7)	<0.001

Variable	Breakpoint	Model 1			Model 2
Variable	Breakpoint	HR (95% CI)	P	LRT (P value)	HR (95% CI)	P	LRT (P value)
MBP SD within 24 h	<8.9	0.88 (0.79, 0.97)	0.013	<0.001	0.86 (0.78, 0.95)	0.004	<0.001
MBP SD within 24 h	≥8.9	1.11 (1.06, 1.16)	<0.001	<0.001	1.10 (1.06, 1.15)	<0.001	<0.001
MBP ARV within 24 h	<6.5	0.85 (0.74, 0.98)	0.03	0.014	0.85 (0.73, 0.98)	0.022	0.008
MBP ARV within 24 h	≥6.5	1.07 (1.01, 1.13)	0.016	0.014	1.08 (1.02, 1.14)	0.005	0.008
MBP Range within 24 h	<39.9	0.98 (0.96, 0.99)	0.009	<0.001	0.98 (0.96, 0.99)	0.008	<0.001
MBP Range within 24 h	≥39.9	1.02 (1.01, 1.03)	<0.001	<0.001	1.02 (1.01, 1.03)	<0.001	<0.001
MBP SV within 24 h	<9.2	0.89 (0.81, 0.98)	0.016	0.002	0.89 (0.81, 0.98)	0.020	0.003
MBP SV within 24 h	≥9.2	1.08(1.03, 1.12)	<0.001	0.002	1.08 (1.03, 1.12)	<0.001	0.003
MBP SD within 48 h	<11	0.91 (0.84, 1.00)	0.038	0.011	0.93 (0.85, 1.01)	0.103	0.026
MBP SD within 48 h	≥11	1.10 (1.02, 1.20)	0.017	0.011	1.10 (1.02, 1.20)	0.018	0.026
MBP ARV within 48 h	<7.3	0.82 (0.72, 0.93)	0.003	0.011	0.84 (0.73, 0.96)	0.009	0.007
MBP ARV within 48 h	≥7.3	1.04 (0.96, 1.13)	0.289	0.011	1.09 (1.00, 1.18)	0.041	0.007
MBP Range within 48 h	<51	0.98 (0.96, 0.99)	0.011	0.007	0.99 (0.97, 1.00)	0.100	0.032
MBP Range within 48 h	≥51	1.02 (1.00, 1.03)	0.025	0.007	1.02 (1.00, 1.03)	0.025	0.032
MBP SV within 48 h	<10.4	0.89 (0.82, 0.98)	0.015	0.018	0.93 (0.85, 1.01)	0.096	0.059
MBP SV within 48 h	≥10.4	1.05 (0.99, 1.11)	0.119	0.018	1.05 (0.99, 1.12)	0.095	0.059
MBP SD within 72 h	<12	0.90 (0.82, 0.98)	0.014	0.005	0.93 (0.85, 1.01)	0.087	0.012
MBP SD within 72 h	≥12	1.17 (1.04, 1.33)	0.011	0.005	1.18 (1.04, 1.33)	0.009	0.012
MBP ARV within 72 h	<8.3	0.81 (0.72, 0.91)	<0.001	0.005	0.86 (0.76, 0.97)	0.016	0.008
MBP ARV within 72 h	≥8.3	1.10 (0.97, 1.24)	0.13	0.005	1.15 (1.02, 1.30)	0.023	0.008
MBP Range within 72 h	<59.7	0.98 (0.96, 0.99)	0.003	0.001	0.98 (0.97, 1.00)	0.061	0.014
MBP Range within 72 h	≥59.7	1.03 (1.01, 1.05)	0.005	0.001	1.02 (1.00, 1.04)	0.013	0.014
MBP SV within 72 h	<10.8	0.86 (0.78, 0.95)	0.004	0.019	0.90 (0.81, 0.99)	0.036	0.027
MBP SV within 72 h	≥10.8	1.05 (0.96, 1.14)	0.267	0.019	1.08 (0.99, 1.17)	0.078	0.027

Variable	Breakpoint	Model 1			Model 2
Variable	Breakpoint	HR (95% CI)	P	LRT (P value)	HR (95% CI)	P	LRT (P value)
MBP SD within 24 h	<8.9	0.88 (0.79, 0.97)	0.013	<0.001	0.86 (0.78, 0.95)	0.004	<0.001
MBP SD within 24 h	≥8.9	1.11 (1.06, 1.16)	<0.001	<0.001	1.10 (1.06, 1.15)	<0.001	<0.001
MBP ARV within 24 h	<6.5	0.85 (0.74, 0.98)	0.03	0.014	0.85 (0.73, 0.98)	0.022	0.008
MBP ARV within 24 h	≥6.5	1.07 (1.01, 1.13)	0.016	0.014	1.08 (1.02, 1.14)	0.005	0.008
MBP Range within 24 h	<39.9	0.98 (0.96, 0.99)	0.009	<0.001	0.98 (0.96, 0.99)	0.008	<0.001
MBP Range within 24 h	≥39.9	1.02 (1.01, 1.03)	<0.001	<0.001	1.02 (1.01, 1.03)	<0.001	<0.001
MBP SV within 24 h	<9.2	0.89 (0.81, 0.98)	0.016	0.002	0.89 (0.81, 0.98)	0.020	0.003
MBP SV within 24 h	≥9.2	1.08(1.03, 1.12)	<0.001	0.002	1.08 (1.03, 1.12)	<0.001	0.003
MBP SD within 48 h	<11	0.91 (0.84, 1.00)	0.038	0.011	0.93 (0.85, 1.01)	0.103	0.026
MBP SD within 48 h	≥11	1.10 (1.02, 1.20)	0.017	0.011	1.10 (1.02, 1.20)	0.018	0.026
MBP ARV within 48 h	<7.3	0.82 (0.72, 0.93)	0.003	0.011	0.84 (0.73, 0.96)	0.009	0.007
MBP ARV within 48 h	≥7.3	1.04 (0.96, 1.13)	0.289	0.011	1.09 (1.00, 1.18)	0.041	0.007
MBP Range within 48 h	<51	0.98 (0.96, 0.99)	0.011	0.007	0.99 (0.97, 1.00)	0.100	0.032
MBP Range within 48 h	≥51	1.02 (1.00, 1.03)	0.025	0.007	1.02 (1.00, 1.03)	0.025	0.032
MBP SV within 48 h	<10.4	0.89 (0.82, 0.98)	0.015	0.018	0.93 (0.85, 1.01)	0.096	0.059
MBP SV within 48 h	≥10.4	1.05 (0.99, 1.11)	0.119	0.018	1.05 (0.99, 1.12)	0.095	0.059
MBP SD within 72 h	<12	0.90 (0.82, 0.98)	0.014	0.005	0.93 (0.85, 1.01)	0.087	0.012
MBP SD within 72 h	≥12	1.17 (1.04, 1.33)	0.011	0.005	1.18 (1.04, 1.33)	0.009	0.012
MBP ARV within 72 h	<8.3	0.81 (0.72, 0.91)	<0.001	0.005	0.86 (0.76, 0.97)	0.016	0.008
MBP ARV within 72 h	≥8.3	1.10 (0.97, 1.24)	0.13	0.005	1.15 (1.02, 1.30)	0.023	0.008
MBP Range within 72 h	<59.7	0.98 (0.96, 0.99)	0.003	0.001	0.98 (0.97, 1.00)	0.061	0.014
MBP Range within 72 h	≥59.7	1.03 (1.01, 1.05)	0.005	0.001	1.02 (1.00, 1.04)	0.013	0.014
MBP SV within 72 h	<10.8	0.86 (0.78, 0.95)	0.004	0.019	0.90 (0.81, 0.99)	0.036	0.027
MBP SV within 72 h	≥10.8	1.05 (0.96, 1.14)	0.267	0.019	1.08 (0.99, 1.17)	0.078	0.027

Variable	Breakpoint	Model 1			Model 2
Variable	Breakpoint	HR (95% CI)	P	LRT (P value)	HR (95%CI)	P	LRT (P value)
MBP SD within 24 h	<8.9	0.85(0.77, 0.95)	0.004	<0.001	0.83 (0.74, 0.92)	<0.001	<0.001
MBP SD within 24 h	≥8.9	1.13 (1.07, 1.19)	<0.001	<0.001	1.11 (1.06, 1.16)	<0.001	<0.001
MBP ARV within 24 h	<6.5	0.86(0.74, 1.00)	0.055	0.023	0.83 (0.70, 0.97)	0.018	0.006
MBP ARV within 24 h	≥6.5	1.08 (1.02, 1.14)	0.013	0.023	1.09 (1.03, 1.15)	0.005	0.006
MBP Range within 24 h	<39.9	0.97 (0.95, 0.99)	0.001	<0.001	0.97 (0.95, 0.99)	<0.001	<0.001
MBP Range within 24 h	≥39.9	1.03(1.01, 1.04)	<0.001	<0.001	1.03 (1.01, 1.04)	<0.001	<0.001
MBP SV within 24 h	<9.2	0.88(0.80, 0.98)	0.016	0.002	0.87 (0.78, 0.96)	0.007	<0.001
MBP SV within 24 h	≥9.2	1.09 (1.04, 1.13)	<0.001	0.002	1.09 (1.04, 1.14)	<0.001	<0.001
MBP SD within 48 h	<11	0.89 (0.81, 0.98)	0.015	0.002	0.90 (0.81, 0.99)	0.039	0.008
MBP SD within 48 h	≥11	1.15 (1.05, 1.25)	0.002	0.002	1.13 (1.04, 1.24)	0.006	0.008
MBP ARV within 48 h	<7.3	0.81 (0.71, 0.93)	0.003	0.008	0.83 (0.71, 0.96)	0.011	0.005
MBP ARV within 48 h	≥7.3	1.07 (0.98, 1.16)	0.148	0.008	1.11 (1.02, 1.22)	0.019	0.005
MBP Range within 48 h	<51	0.97 (0.95, 0.99)	0.002	<0.001	0.98 (0.96, 1.00)	0.030	0.007
MBP Range within 48 h	≥51	1.03 (1.01, 1.04)	0.002	<0.001	1.02 (1.01, 1.04)	0.006	0.007
MBP SV within 48 h	<10.4	0.90 (0.81, 0.99)	0.03	0.021	0.93 (0.84, 1.02)	0.133	0.062
MBP SV within 48 h	≥10.4	1.06 (1.00, 1.13)	0.068	0.021	1.06 (1.00, 1.14)	0.061	0.062
MBP SD within 72 h	<12	0.84 (0.76, 0.93)	<0.001	<0.001	0.86 (0.78, 0.95)	0.004	<0.001
MBP SD within 72 h	≥12	1.30 (1.13, 1.49)	<0.001	<0.001	1.27 (1.11, 1.45)	<0.001	<0.001
MBP ARV within 72 h	<8.3	0.78 (0.68, 0.89)	<0.001	0.001	0.82 (0.71, 0.94)	0.005	0.001
MBP ARV within 72 h	≥8.3	1.16 (1.01, 1.33)	0.033	0.001	1.22 (1.06, 1.40)	0.004	0.001
MBP Range within 72 h	<59.7	0.96 (0.95, 0.98)	<0.001	<0.001	0.97 (0.95, 0.99)	0.004	0.002
MBP Range within 72 h	≥59.7	1.04 (1.02, 1.06)	<0.001	<0.001	1.03 (1.01, 1.05)	0.006	0.002
MBP SV within 72 h	<10.8	0.84 (0.75, 0.94)	0.002	0.007	0.87 (0.77, 0.97)	0.014	0.009
MBP SV within 72 h	≥10.8	1.08 (0.98, 1.18)	0.103	0.007	1.11 (1.01, 1.22)	0.031	0.009

重症蛛网膜下腔出血患者入院早期平均动脉压变异性与院内死亡风险的U形关系：基于MIMIC-IV和eICU-CRD数据库

Early mean arterial pressure variability and in-hospital mortality from severe subarachnoid hemorrhage: a U-shaped association based on MIMIC-IV and eICU-CRD data

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