南方医科大学学报

南方医科大学学报 ›› 2022, Vol. 42 ›› Issue (10): 1539-1544.doi: 10.12122/j.issn.1673-4254.2022.10.14

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肝癌晚期患者转化治疗前后心理痛苦及生活质量的调查

潘立茹，张雯雯，胡丙洋，李俊锋，冯 宇，邓 芬，杨 莉，周 静，马微微，姜翠翠，徐 艳，卢实春   

  1. 解放军总医院第一医学中心肝胆胰外科医学部，消化内科医学部北京，普通外科医学部，北京 100853，解放军总医院第六医学中心中医医学部，北京 100853
  • 出版日期:2022-10-20 发布日期:2022-10-31

Comparison of psychological distress and quality of life in patients with advanced liver cancer before and after transformation therapy

PAN Liru, ZHANG Wenwen, HU Bingyang, LI Junfeng, FENG Yu, DENG Fen, YANG Li, ZHOU Jing, MA Weiwei, JIANG Cuicui, XU Yan, LU Shichun   

  1. Department of Hepatobiliary and Pancreatic Surgery, Department of Gastroenterology, Department of General Surgery, First Medical Center, PLA General Hospital, Beijing 100853, China; Department of Traditional Chinese Medicine, Sixth Medical Center of PLA General Hospital, Beijing 100853, China
  • Online:2022-10-20 Published:2022-10-31

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摘要： 目的 观察并分析晚期肝癌患者在转化治疗前后心理痛苦及生活质量变化情况，以期为临床开展心理干预等提供参考，同时为序贯外科手术治疗做好前期准备。方法 选取2019年7月~2022年3月的60例进行转化治疗的患者，治疗前及治疗2~10个周期后，采用心理痛苦温度计及其问题列表测定心理痛苦程度变化，采用肝胆肿瘤治疗功能评定量表测定患者生活质量。结果 转化治疗后，患者心理痛苦的分值与转化治疗前比较明显降低（P<0.01）；转化治疗后心理痛苦情绪因素紧张、担忧、睡眠问题、记忆力下降和注意力不集中，身体因素疼痛、疲乏、进食问题、消化不良比例明显下降，差异有统计学意义（P<0.05）；转化治疗后，生活质量总分及其中的身体状况、社交/家庭状况、情感状况、功能状况及肝胆特异板块评分较治疗前明显下降（P<0.05）。结论 晚期肝癌患者心理痛苦因素主要集中于情绪因素和身体因素，转化治疗可以明显降低患者心理痛苦程度和提高患者生活质量。

关键词: 肝癌晚期；转化治疗；心理痛苦温度计；肝胆肿瘤治疗功能评定量表

Abstract: Objective To analyze the changes in psychological distress and quality of life of patients with advanced liver cancer after transformation therapy. Methods This study was conducted among 60 patients with advanced liver cancer undergoing transformation therapy from July, 2019 to March, 2022. Before and after 2-10 cycles of treatment, the patients were assessed for psychological distress and quality of life using a psychological stress thermometer and the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep). Results The patients showed significantly lowered scores for psychological distress after transformation therapy (P<0.01) with decreased psychological stress, emotional factors, tension, worry, sleep problems, memory decline and inattention, physical factors, pain, fatigue, eating problems and dyspepsia (P<0.05). The total score of quality of life and the scores for physical status, social and family status, emotional status, functional status and hepatobiliaryspecific items were all significantly lowered after the treatment (P<0.05). Conclusion In patients with advanced liver cancer, the psychological distress involves mainly the emotional factors and physical factors. Transformation therapy can significantly relieve psychological distress of the patients and improve their quality of life.

Key words: advanced liver cancer; transformation therapy; Psychological Distress Thermometer; Functional Assessment of Cancer Therapy-Hepatobiliary