南方医科大学学报

南方医科大学学报 ›› 2022, Vol. 42 ›› Issue (5): 766-771.doi: 10.12122/j.issn.1673-4254.2022.05.20

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运动调控纹状体听觉响应的神经机制

黄威龙，梁妃学   

  1. 南方医科大学生物医学工程学院数学物理系，广东 广州 510515
  • 出版日期:2022-05-20 发布日期:2022-06-02

Neural mechanism for modulation of auditory response of the striatum by locomotion

HUANG Weilong, LIANG Feixue   

  1. Department of Mathematical Physics, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China
  • Online:2022-05-20 Published:2022-06-02

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摘要： 目的 研究动物处于不同行为状态时，纹状体听觉神经元对声音信息的特征表达是否被调控。方法 以SPF级C57BL/6J清醒小鼠纹状体的听觉神经元为研究对象，通过搭建同步的在体电生理和运动记录系统，采用玻璃微电极贴附式记录方法长时间记录纹状体听觉神经元对噪声的听觉响应，并通过分析小鼠跑动速度将小鼠的行为状态分为安静状态和运动状态，分析动物处于两种行为状态下纹状体听觉神经元的自发活动和诱发响应。结果 相对于安静状态，当动物处于运动状态时，纹状体听觉神经元的自发活动增高（37.06±12.02 vs 18.51±10.91，P<0.001），而诱发响应下降（噪声强度=60 dB，3.45±2.99 vs 3.04±2.76，P<0.001）。结论 运动状态对纹状体的听觉响应具有显著的抑制作用，这可能是导致运动状态时声音信息的识别能力下降的重要原因。

关键词: 运动调控；纹状体；听觉神经元；听觉响应

Abstract: Objective To explore whether the characteristic responses to sound stimulations of the auditory neurons in the striatum is regulated in different behavioral states. Methods The auditory neurons in the striatum of awake C57BL/6J mice were selected for this study. We recorded the auditory response of the striatum to noises over a long period of time by building a synchronous in vivo electrophysiological and locomotion recording system and using glass microelectrode attachment recording. By analyzing the running speed of the mice, the behavioral states of the mice were divided into the quiet state and the active state, and the spontaneous activity and evoked responses of the auditory neurons in the striatum were analyzed in these two states. Results Compared with those recorded in the quiet state, the spontaneous activity of the auditory neurons in the striatum of the mice increased significantly (37.06±12.02 vs 18.51±10.91, P<0.001) while the auditory response of the neurons decreased significantly (noise intensity=60 dB, 3.45±2.99 vs 3.04±2.76, P<0.001) in the active state. Conclusion Locomotion has a significant inhibitory effect on the auditory response of the striatum, which may importantly contribute to the decline of sound information recognition ability in the active state.

Key words: locomotion modulation; striatum; auditory neurons; auditory response