南方医科大学学报

南方医科大学学报 ›› 2022, Vol. 42 ›› Issue (3): 443-447.doi: 10.12122/j.issn.1673-4254.2022.03.19

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体外循环术后早期升高的C反应蛋白与术后心房颤动有关

何 勇，刘四云，罗永金，吴洪坤，余 杨，陈 灏   

  1. 中国科学院大学重庆医院//重庆市人民医院，重庆 401120
  • 出版日期:2022-03-20 发布日期:2022-04-11

Elevation of C-reactive protein early after cardiopulmonary bypass surgery is associated with occurrence of postoperative atrial fibrillation

HE Yong, LIU Siyun, LUO Yongjin, WU Hongkun, YU Yang, CHEN Hao   

  1. Chongqing General Hospital//Chongqing People's Hospital, University of Chinese Academy of Science, Chongqing 401120, China
  • Online:2022-03-20 Published:2022-04-11

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摘要： 目的 探讨术后C反应蛋白水平与术后房颤发生情况的关系。方法 回顾性分析我院2018年9月~2021年5月期间进行体外循环手术的550例患者，根据排除标准进行研究对象的筛选，最终入选患者363例，采用非参数检验（两独立样本Wilcoxon秩和检验）对年龄、术后早期C反应蛋白与术后房颤发生情况进行单因素分析，采用χ2检验分析研究对象性别、疾病类型、合并症发生情况与术后房颤发生情况的关系；多因素分析采用二分类logistic回归。结果 本次研究中共入组363例患者，其中瓣膜病247例，主动脉夹层42例，冠心病37例，先天性心脏病37例。术后房颤发生人数101人，发生率为27.82%；术后C反应蛋白中位数88.65 mg/L，年龄中位数为57岁，最小5岁，最大77岁；将研究对象根据术后心房颤动的发生分为房颤组和窦性组。使用单因素和多因素相关性研究显示，术后早期C反应蛋白是术后心房颤动发生的重要因素。结论 术后早期升高的C反应蛋白与术后房颤的发生有关系。

关键词: 术后房颤；体外循环；心脏手术；C反应蛋白

Abstract: Objective To explore the association between postoperative C-reactive protein (CRP) levels and the occurrence of postoperative atrial fibrillation in patients undergoing cardiopulmonary bypass surgery. Methods We retrospectively analyzed the data of 550 patients undergoing cardiopulmonary bypass surgery in our hospital from September, 2018 to May, 2021, and after screening against the exclusion criteria, 363 patients were selected for further analysis. Univariate analysis was used to analyze the correlation of age and early postoperative CRP level with the occurrence of postoperative atrial fibrillation, and Chi-square test was used to explore the correlation of gender, disease type, and comorbidity with postoperative atrial fibrillation followed by multivariate analysis of the data using a binary logistic regression model. Results The 363 patients enrolled in this study included 247 with valvular disease, 42 with aortic dissection, 37 with coronary heart disease, and 37 with congenital heart disease, with a median postoperative CRP level of 88.65 mg/L and a median age of 57 years (range 5-77 years). Postoperative atrial fibrillation occurred in 101 (27.82%) of the patients, who were subsequently divided into atrial fibrillation group and sinus group. Univariate and multivariate correlation analyses showed that early postoperative elevation of CRP level was an important factor contributing to the occurrence of postoperative atrial fibrillation. Conclusion Early postoperative elevation of CRP level is associated with the occurrence of atrial fibrillation following cardiopulmonary bypass surgery.

Key words: postoperative atrial fibrillation; cardiopulmonary bypass; cardiac surgery; C-reactive protein