Abstract: ObjectiveTo investigate the correlation between the findings by coronary computed tomography angiography
(CCTA) and the risk factors for major adverse cardiac events (MACE). MethodsThis cohort study involved706out-patients
who received examination with CCTA between June,2008and April,2011. The severity of coronary artery disease (CAD) was
graded to normal, mild, moderate, severe, and revascularization. Pearson correlation analysis and ANOVA were used to
evaluate the relationship between the risk factors for CAD and coronary plaques identified by CCTA, and the predictive
accuracy was determined by the receiver-operating characteristic (ROC) curve.ResultsOf the706patients,58.63% were found
to have abnormal CCTA findings. A older age, hypertension, hyperlipidemia, diabetes mellitus, cerebral infarction, CAD, and
myocardial infarction were associated with an significantly increased incidence of coronary plaques (P<0.01). The Framingham
score, LDL, HCY, IMT, HDL and TC were also significantly correlated with the severity of the coronary plaques (P<0.05). The
ROC curves showed that Framingham risk score (0.845), Cr (0.766), HCY (0.697), IMT (0.693) and HDL (0.316) had greater
predictive value for the occurrence of coronary plaques (P<0.001).ConclusionThe Framingham risk score, Cr, HCY, IMT and
HDL are validated by CCTA as the major coronary risk factors and can be used for screening of CAD.