Abstract: Objective To investigate the correlation of the levels of interleukin-8 (IL-8) and IL-6 in the prostatic fluid with serum
levels of serum prostate-specific antigen (PSA) in patients with benign prostatic hyperplasia (BPH) complicated by prostatitis.
Methods A series of 211 patients undergoing surgery of BPH were divided into BPH group (n=75) and BPH with prostatitis
group (n=136) according to the white blood cell count in the prostatic fluid. The clinical and laboratory findings were
compared between the two groups, and stepwise regression analysis was used to assess the association of IL-8 and IL-6 with
serum PSA level. Results No significant differences were found in age, BMI, blood pressure, blood glucose, blood lipids, IPSS
score, PSA-Ratio, or prostate volume between the two groups (P>0.05). The patients with prostatitis had significantly increased
serum PSA and prostate fluid IL-8 and IL-6 levels compared with those without prostatitis (P<0.001). Multiple linear regression
analysis showed that IL-8 and IL-6 levels and white blood cell count in the prostatic fluid were all positively correlated with
serum PSA level. Conclusion Prostatitis is an important risk factor for elevated serum PSA level in patients with BPH, and
both IL-8 and IL-6 levels in the prostatic fluid are correlated with serum PSA level.