Abstract: Objective To assess the effects of continuous blood purification (CBP) on extravascular lung water and respiratory
function in patients with extrapulmonary acute respiratory distress syndrome (ARDSexp). Methods The data of 31 patients
with ARDSexp admitted in our department were retrospectively analyzed．Sixteen of the patients received CBP, and the other
15 patients did not (control group). The level of extravascular lung water index (EVLWI), pulmonary vascular permeability
index (PVPI), and respiratory function were measured before and after CPB. Results The mortality rate was significantly lower
in CBP group than in the control group (12.5% vs 33.3%, P<0.05). The patients in CPB group showed markedly earlier and
significantly greater improvements in EVLWI, PVPI, PaO2/FiO, and respiratory function than the control patients (P<0.05).
Conclusion CBP can reduce EVLWI and PVPI, improve pulmonary compliance and oxygenation, and reduce mortality rate in
patients with ARDSexp.