Abstract: Gestational trophoblastic tumors (GTTs) are malignant lesions that often cause abnormal genital bleeding and may
present with hemoptysis, intraperitoneal bleeding or acute neurologic deficits. GTTs are generally highly chemosensitive with
more favorable outcomes than other comparable malignancies. Here we report a rare case of invasive mole (FIGO stage IV,
WHO score16) presenting with renal subcapsular hematoma due to bleeding renal metastasis. The patient had a pretreatment
β-human chorionic gonadotrophin (β-HCG) level of 462 047 mIU/ml and received combined chemotherapy with etoposide,
methotrexate, actinomycin-D, cyclophosphamide and vincristine with also adjuvant surgeries including hysterectomy and
nephrectomy. The patient recovered well and the tumor has remained in complete remission for one year and a half.