Abstract: We report 3 cases of polycystic ovary syndrome (PCOS) in which the patients had successful pregnancy after
repeated implantation failure in at least 8 in vitro fertilization and embryo transfer (IVF-ET) cycles. The patients were treated
with gonadotropin-releasing hormone antagonist (GnRH-ant) protocol and gonadotropin-releasing hormone angonist
(GnRHa) for triggering ovulation, and successful pregnancy and normal deliveries were achieved after 9 IVT-ET cycles. For
young patients with PCOS but a good ovarian reserve and a high ovarian response, treatment with GnRH antagonist protocol
and GnRHa alone with appropriate management of the factors that may affect implantation can prevent severe ovarian
hyperstimulation syndrome to achieve favorable clinical outcomes.