Abstract: Objective To study the changes in 24-hour video electroencephalogram (EEG) and epileptic attacks after
levetiracetam add-on therapy in children with frontal lobe epilepsy and epileptiform discharges. Methods A prospective study
was carried out in 105 children with the frontal lobe epilepsy who received long-term treatment with 1 or 2 types of
antiepileptic drug but still with epileptiform discharges in ECG. Levetiracetam add-on therapy was administered at the initial
daily dose of 20 mg/kg (given in 2 doses) for 2 weeks followed by an increase of the dose to 30 mg/kg with a maintenance dose
of 30-40 mg/kg. The changes in seizure attacks and 24-hour video-EEG monitoring after a 6-month therapy were observed.
Results Levetiracetam add-on therapy reduced epileptiform discharges in 55 children (52.3% ) and resulted in significant
changes in EEG (P<0.05). Of the 77 children with clinical seizures, complete seizure control was achieved in 12 cases after the
therapy, and the seizure attacks were reduced in 28 cases, showing a total response rate of 51.9%; the reduction in seizure
attacks was positively correlated with EEG improvement (P<0.001). Conclusion Levetiracetam add-on therapy can decrease
epileptiform discharges in EEG and reduce clinical seizure attacks in children with frontal lobe epilepsy with only mild
adverse reactions.