Abstract: Objective To evaluate the association between leptin receptor gene polymorphisms and hypertension in Chinese
population. Methods The keywords "Hypertension", "Blood Pressure, high", "Leptin Receptor", "OB Receptor", "LEPR Protein",
"CD295 Antigens", and "LEPR" were used to search the literature to identify the relevant studies for meta-analysis using
software RevMan 5.0 and Stata 11.0 software. Results Thirteen studies involving 3210 cases of hypertension and 1881 controls
were included in the meta-analysis. Overall, a significant association was found between Gln223Arg gene polymorphism and
hypertension in allele contrast and dominant genetic model (for allele contrast genetic model: OR=1.17, 95%CI=1.48-2.15, P<
0.0001; for dominant model: OR=2.18, 95%CI=1.75-2.72, P<0.00001). No statistically significant correlation was found between
Lys109Arg polymorphism and hypertension (for allele model: OR=1.13, 95%CI=0.84-1.51, P=0.42; for recessive genetic model:
OR=0.88, 95%CI=0.33-2.32, P=0.79; for dominant genetic model: OR=1.20, 95%CI=0.85-1.71, P=0.29; for additive genetic model:
OR=0.90, 95%CI=0.34-2.42, P=0.84). Conclusion There is no significant correlation between Lys109Arg variant of LEPR gene
and hypertension in Chinese population, but the Gln223Arg polymorphism is associated with hypertension in allele contrast
and dominant genetic model. Chinese population with an Aallele are at a high risk of developing hypertension.