Journal of Southern Medical University ›› 2014, Vol. 34 ›› Issue (02): 210-.
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Abstract: Objective To investigate the correlation between miR-124 rs531564 polymorphisms and the susceptibility to cervicalcancer in Chinese Han women in Guangdong Province. Methods The genotypes of miR-124 rs531564 polymorphism weredetermined using polymerase chain reaction-based ligase detection reaction (PCR-LDR) in 107 cervical cancer patients and 208healthy female blood donors. The correlation between the polymorphism and the susceptibility to cervical cancer wasevaluated using unconditional logistic regression analysis. Results The incidence of HPV infection in the patients (93.1%) wasmuch higher than that in the control subjects (16.8%, P<0.001), suggesting the importance of HPV infection as a critical riskfactor for cervical cancer. The G allele of miR-124 rs531564 polymorphism in the cervical cancer patients was much lessfrequent than that in the controls (8.0% vs 15.1%, P=0.014), suggesting its possible role as a protective allele. Compared withthose carrying CC genotype, individuals carrying the CG and GG genotypes showed a significantly reduced risk for cervicalcancer (OR=0.47, 95% CI=0.26-0.88, P=0.017), and this protective role of the G allele was more prominent in older women (≥45years old) (OR=0.28, 95% CI=0.10-0.76, P=0.012). Conclusion miR-124 rs531564 polymorphism may play a role in cervicalcancer susceptibility in Chinese Han women, and G allele is associated with a reduced risk of cervical cancer.
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https://www.j-smu.com/EN/Y2014/V34/I02/210