Journal of Southern Medical University ›› 2014, Vol. 34 ›› Issue (02): 193-.
Previous Articles Next Articles
Online:
Published:
Abstract: Objective To investigate the antineoplastic effects of 2-Deoxy-D-glucose (2-DG) combined with Taxol onorthotopically transplanted breast cancer in C3H mice and explore the mechanism. Methods C3H mice bearing orthotopicallytransplanted breast cancer xenograft were randomly divided into 4 groups, namely the control group, 2-DG group, Taxolgroup, and 2-DG+Taxol group. The corresponding drugs were administered intraperitoneally every 3 days for 18 consecutivedays, and the tumor volume was measured every 3 days to draw the tumor growth curve. The mice were then sacrificed tomeasure the tumor weight on day 19 and examine tumor cell apoptosis with TUNEL assay and VEGF expression usingimmunohistochemistry. Results 2-DG combined with Taxol obviously suppressed the tumor growth with a tumor inhibitionrate of 66.06% as compared to the rate of 36.97% in Taxol group. The combined treatment also caused more obvious cellapoptosis and significantly reduced VEGF expression in the tumor cells as compared with the other groups. Conclusion 2-DGcan enhance the inhibitory effect of Taxol on orthotopically transplanted breast cancer xenograft in C3H mice probably byinducing tumor cell apoptosis and lowering VEGF expressions.
0 / / Recommend
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.j-smu.com/EN/
https://www.j-smu.com/EN/Y2014/V34/I02/193