Abstract: Objective To investigate the relationship between the 3 polymorphic loci of endothelin receptor type A (EDNRA)
gene and intracranial aneurysms. Methods Three EDNRA gene polymorphisms (rs5335, rs6842241, and rs6841581) were
genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis. The genotype and allele
frequencies were calculated in the patients and the control group to analyze the association between the gene and the size of
aneurysms. Results No significant difference was found in the distribution of the EDNRA gene genotypes or allele frequencies
between the patients and the control subjects. Only GG genotype of rs6841581 was found to significantly correlate with the size
of aneurysms. Conclusion EDNRA gene rs6841581 has significant associations with the size of intracranial aneurysms,
indicating a possible role of EDNRA in the genetic mechanisms of intracranial aneurysms and subarachnoid hemorrhage.