Journal of Southern Medical University ›› 2013, Vol. 33 ›› Issue (12): 1778-.
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Abstract: Objective To detect the expression of signal transducer and activator of transcription 3 (STAT3) and P-STAT3 in thebrain of the APPswe/PS △E9 double transgenic mouse model of Alzhaimer’s disease (AD) and invesitgate their possible role inAD. Methods APPswe/PS △E9 double transgenic mice and control mice were examined for cerebral STAT3 and P-STAT3expressions using immunothistochemistry. Results STAT3 and P-STAT3 were expressed in the different regions of mousebrain. In the transgenic mice and the control mice, the positivity rates of STAT3 were 93.75% and 87.50% in the cerebral cortex,87.50% and 43.75% in the basal forebrain, 81.25% and 37.50% in the hippocampus, and 62.50% and 0.00% in the cerebellum,respectively, showing significant differences between the mice in the STAT3 expressions in the basal forebrain, hippocampusand cerebellum (P<0.05). The positivity rates of P-STAT3 in the two groups were 0.00% and 0.00% in the cerebral cortex, 68.75%and 0.00% in the basal forebrain, 62.50% and 12.50% in the hippocampus, and 43.75% and 0.00% in the cerebellum,respectively, showing also significant differences in the basal forebrain, hippocampus and cerebellum (P<0.05). The expressionof STAT3 was positively correlated with that of P-STAT3 in transgenic AD mice (P<0.05). Conclusion STAT3 and P-STAT3 arehighly expressed in the basal forebrain, hippocampus and cerebellum in transgenic AD mice and may participate in thepathological process of AD.
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https://www.j-smu.com/EN/Y2013/V33/I12/1778