Abstract: Objective To study the changes in sexual function in premenopausal women after renal transplantation. Methods
Forty-two married premenopausal women receiving dialysis therapy for at least 6 months with normal renal function for 6
months after renal transplantation were examined for hormonal profiles and menstrual cycles. The sexual functions of the
patients were evaluated using Female Sexual Function Index (FSFI) before and 6 months after the transplantation. Results
Before renal transplantation, amenorrhea, oligomenorrhea, polimenorrhea, and eumenorrhea were found in 18 cases (42.9%),
10 cases (23.8%), 5 cases (11.9%) and 9 cases (21.4%), as compared to 7 cases (16.7%), 5 cases (11.9%), 6 cases (14.3%) and 24
cases (57.1% ) after the transplantation, respectively. Prolactin (PRL), follicle-stimulating hormone (FSH) and luteinizing
hormone (LH) levels significantly decreased and estradiol (E2) and progesterone (P) significantly increased after renal
transplantation (P<0.001). Nineteen patients (45.2%) before and 36 patients (85.7%) after the surgery reported to have an active
sexual life (P<0.001). The total incidences of female sexual dysfunction before and after kidney transplantation were 90.5% and
40.5% (P<0.001), respectively. The scores for sexual desire, arousal, lubrication, satisfaction, orgasm, and pain in FSFI were
significantly increased after kidney transplantation (P<0.001). Conclusion A successful renal transplantation can significantly
improve sexual functions in premenopausal women.