Abstract: Objective To evaluate the impact of preoperative platelet-lymphocyte ratio (PLR) on the prognosis in patients with
operable colorectal cancer. Methods The clinical data of 140 patients with operable colorectal cancer were analyzed
retrospectively. According to preoperative PLR, the patients were divided into low PLR group (PLR<250) and high PLR group
(PLR≥250). The overall 5-year survival rates and the clinicopathological factors in the two groups were analyzed using
univariate analysis and COX regression model. Results The patients with a high PLR had a significantly lower overall 5-year
survival rate than those with a low PLR (71.4% vs 51.5%, P=0.045). Univariate analyses identified tumor location, the depth of
tumor invasion, lymph nodes metastasis, TMN stage, and PLR as significant risk factors for reduced overall 5-year survival. In
COX regression model, a high PLR was identified as an independent risk factor for poorer prognosis in patients with
resectable colorectal cancer (RR: 2.213; 95% CI: 1.007-4.863, P=0.0048). Conclusion Preoperative PLR can be a clinically
significant factor for assessment of prognosis of resectable colorectal cancer.