Abstract: Objective To study the correlation between the expression levels of phagocytic NADPH oxidase p22phox subunit
and left ventricular mass index (LVMI) in patients with non-valvular chronic heart failure and explore the role of oxidative
stress caused by NADPH oxidase p22phox subunit in left ventricular remodeling. Methods Semi-quantitative RT-PCR was
used to examine the expression levels of phagocytic NADPH oxidase p22phox in 59 patients with non-valvular chronic heart
failure and 20 control subjects. All the subjects underwent ultrasonic cardiography to record their IVST, LVPWT, LVEDd,
LVEDs, and EF. Based on the calculated LVMI, the patients were divided into heart failure without LV hypertrophy (LVH)
group and heart failure with LVH group. Results The patients with heart failure showed significantly higher expression of
phagocytic NADPH oxidase p22phox than the control subjects (0.91±0.37 vs 0.68±0.33, P=0.039), and the patients with LVH had
significantly higher p22phox expression than those without LVH (1.58±0.20 vs 0.71±0.24, P=0.026). LVMI showed a positive
correlation with the expression of p22phox in these patients (r=0.508, P<0.05). Conclusion NADPH oxidase p22phox
expression level is positively correlated with LVMI and can be indicative of the level of left ventricular remodeling in patients
with non-valvular chronic heart failure.