Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (08): 1219-1221.

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Helicobacter pylori induces damage of HepG2 cells in vitro

CHEN Ren, CHEN Xiao-ping Department of Infectious Diseases, Guangdong Provincial People’s Hospital, Guangzhou 510080, China   

  1. 广东省人民医院感染科; 广东省人民医院感染科 广东广州510080; 广东广州510080;
  • Online:2006-08-20 Published:2006-08-20

Abstract: HepG2 cells were treated with Helicobacter pylori (Hp) at different concentrations and the cell killing and apoptosis of the cells were measured with MTT assay and Hoechst 33258 staining technique. The results showed that with the increment of cagA (+) Hp concentration, HepG2 cell killing and apoptosis rate increased in a concentration-dependent manner, but cagA (-) Hp did not significantly impacted on the proliferation and apoptosis of HepG2. 

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