Abstract: Objective To investigate the feasibility of dynamic magnetic resonance diffusion tensor imaging(DTI) in rabbit models with implanted VX2 hepatic tumor grafts.Methods MRI and DTI images were obtained from 16 rabbit models with implanted VX2 hepatic tumor grafts(14,18,22,and 26 days after tumor implantation,respectively) and 4 normal rabbits.The average diffusion coefficient(ADC) and exponential ADC(eADC) were estimated and compared against pathological findings.Results The ADC values increased after tumor implantation but then decreased in the rabbit models,whereas eADC exhibited a pattern of reverse changes.These changes significantly differed from those in the control group.Coagulation necrosis and fibrous hyperplasia showed obvious increase as found by pathological examination.Conclusion Dynamic MR DTI quantitative analysis of rabbit models of implanted VX2 hepatic tumor can partially describe the growth behaviors of implanted liver cancer.