Effects of short-term chemotherapy on the compliance of rabbit abdominal aorta

Abstract

Abstract: Objective To investigate the effect of short-term chemotherapy on the compliance of rabbit abdominal aorta, and understand the changes in the biomechanical properties of the blood vessels after chemotherapy. Methods Fifteen rabbits were divided into 5 groups, 4 of which were subjected to injection with chemotherapeutic agents for 5 days to evaluate the compliance of the abdominal aorta at 2, 7, 14, and 21days after the therapy with the other group without chemotherapy serving as the control. Results The compliance of the abdominal aorta was obviously decreased after chemotherapy and reached the lowest level 14 days after short-term chemotherapy, suggesting that the drugs resulted in vascular injury enough toalter the biomechanical properties of the blood vessels. Conclusion Short-term chemotherapy can decrease the compliance of the blood vessels, which may deteriorate with time but such changes can be reversible.

CLC Number:

R733.9

SHEN Ce¹, LIU Hao¹, ZUO Qiang², ZHANG Jun-yi², YANG Jin-xing². Effects of short-term chemotherapy on the compliance of rabbit abdominal aorta[J]. Journal of Southern Medical University, 2005, 25(11): 1443-1445.

References

[1] Wynendaele W, van-Oosterom AT. Neoadjuvant/primary chemotherapy in cancer treatment: what advantage[J] ? Forum-(Genova), 1999,9(3): 212-21.
[2] 赵健,吴一龙,王远东,等.新辅助化疗对乳腺癌雌、孕激素受体和HER-2的影响[J].第一军医大学学报,2004,24(12):1437-9.Zhao J, Wu YL, Wang YD, et al. Effects of neoadjuvant chemotherapy on estrogen and progesterone receptors and HER-2 in breast cancer[J]. J First Mil Med Univ/Di Yi Jun Yi Da Xue Xue Bao,2004, 24(12): 1437-9.
[3] Matsumoto A. Problems in Neoadjuvant chemoradiotherapy preceding surgery for advanced squmous cell carcinoma of the thoracic esophagus[J]. Jpn J Thorac Cardiovasc Surg, 1999, 47(6): 262-6.
[4] 李成则.实用动物实验技术[M].北京:机械出版社,1994.32-5.
[5] 余汇洋,陈尔瑜.动脉吻接后的顺应性变化[J].生物医学工程学杂志(J Biomed Eng),1995,12(4):300-3.
[6] van der Hage JA, van de Velde CJ, Julien JP, et al. Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer Trial 10902[J]. J Clin Oncol, 2001, 19(22): 4224-37.
[7] Machtay M, Lee JH, Stevenson JP, et al. Two commonly used neoadjuvant chemoradiotherapy regimens for locally advanced stage Ⅲ non-small cell lung carcinoma: long-term results and associations with pathologic response[J]. J Thorac Cardiovasc Surg, 2004, 127(1): 108-13.
[8] Cappuzzo F, Selvaggi G, Gregorc V, et al. Gemcitabine and cisplatin as induction chemotherapy for patients with unresectable Stage ⅢAbulky N2 and Stage Ⅲ B nonsmall cell lung carcinoma: an Italian Lung Cancer Project Observational Study[J]. Cancer, 2003, 98 (1):128-34.
[9] Napolitano V, Imperato F, Mossa B, et al. The role of Neoadjvant Chemotherapy for squamous cell cervical cancer (Ⅰb～Ⅲb): a long term randomized trial[J]. Eur J Gynaecol Oncol, 2003, 24(1): 51-7.
[10] Barer GR. Pulmonary hypertensive effect of lung inflation in chronic hypoxia: a study in rats[J]. Eur Respir J, 1998, 12(2): 277-83.
[11] van-Gorp AW, Schenau DS, Hoeks AP, et al. In spontaneously hypertensive rats alterations in aortic wall properties precede development of hypertension[J]. Am J Physiol Heart Circ Physiol, 2000,278(4): H1241-7.
[12] 钱畅,陈长才.颅脑火器伤早期脑微血管三维构型和超微结构实验研究[J].第一军医大学学报,2004,24(7):765-7.Qian C, Chen CC. Three-dimensional architecture and ultrastructure of the cerebral microvasculature of missile brain wound in cats[J]. J First Mil Med Univ/Di Yi Jun Yi Da Xue Xue Bao, 2004, 24(7):765-7.