Abstract: Objective To study the clinical significance of expressions of tumor necrosis factor receptorⅠ and Ⅱ(TNFRⅠ and Ⅱ) and their relationship with clinical pathology in human gastric carcinoma. Methods SABC immunohistochemical method was used to examine the expressions of TNFRⅠ and Ⅱ in 51 cases of gastric carcinoma, 41 adjacent mucosal and 15 normal gastric mucosa tissues. Results The positivity rates of TNFRⅠ and Ⅱ expressions in human gastric carcinoma were significantly higher than those in the adjacent mucosal and normal mucosal tissues, and their expressions were significantly higher in the surrounding mucosa than in the normal tissues. In gastric carcinoma tissues, no correlations of TNFRⅠ and Ⅱ expressions with serous membrane invasion or lymph node metastasis were found, but the differentiation grade was positively correlated with TNFR expressions (r=-0.3111, P=0.035; r=-0.5952, P=0.000, respectively). Conclusion TNFRⅠ and Ⅱ expressions are valuable indicators for determining the malignancy and predicting the differentiation grade of gastric carcinoma.