Expression of pulmonary surfactant-associated protein D and its significance in human fetal lung

Abstract

Abstract: Objective To observe the expression of pulmonary surfactant-associated protein D (SP-D) during human fetal lung development.Methods Human fetal lung tissues from 11- to 36-week-old fetuses were assayed for lung maturity with HE staining and SP-D expression by means of immunohistochemistry.Results SP-D expression was located in the bronchial epithelium and alveolar epithelial type Ⅱ cells(AECⅡ) of the lung tissues since the 12th week, and gradually increased during the canalicular to saccular stages with fetal development, at the point of which SP-D-positivity began a shift from the proximal bronchial epithelium to AECⅡ,and evidently located in the alveoli from the advanced stage of lung development till postnatal stage.Conclusions SP-D expression gradually intensifies with the maturation of the fetal lungs, and SP-D-positive cells begin to be detected in the bronchial epithelium and finally in AECⅡ.

CLC Number:

R-33
R72

CHEN Yue, DU Jiang, ZHAO Qian, FENG Zhi-chun. Expression of pulmonary surfactant-associated protein D and its significance in human fetal lung[J]. Journal of Southern Medical University, 2005, 25(03): 329-331.

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