Deep venous thrombosis in the lower extremities following renal transplantation: causes and management

Abstract

Abstract: Objective To investigate the causes, prevention measures and treatment of deep venous thrombosis in the lower extremities (LDVT) following renal transplantation. Method Thirty-eight renal transplant recipients who developed LDVT following the transplantation were analyzed for the causes, evidence for diagnosis, prevention measures and treatment of LDVT. Results The 38 cases were diagnosed by B-mode ultrasound and systemic modical history review and after timely and effective therapy, all the patients recovered between 3 to 20 d, showing evidence of establishment of efficient collateral circulation as found in color Doppler ultrasound examination. Conclusion Following renal transplantation, the recipients are exposed to greater risks of developing LDVT, for which B-mode ultrasound provides the most effective diagnosis. The patients generally respond well to timely interventions with anticoagulation, clot removal and thrombolysis, and preventive measures are indicated in those at high risk of LDVT following transplantation.

CLC Number:

R543.6

YU Li-xin, LI Chuan-jiang, DENG Wen-feng. Deep venous thrombosis in the lower extremities following renal transplantation: causes and management[J]. Journal of Southern Medical University, 2004, 24(12): 1342-1345.

References

[1] Leasing AWA, Prandoni P, Prins MH, et al. Deep-vein thrombosis[J]. Lancet, 1999, 6(353): 479-85.
[2] Charles A. Deep venous thrombosis,an overview [J]. Angiology,1990, 41(5): 337-51.
[3] Mary E, Eberst MD, Lee R, et al. Hemostasis in renal diseases: pathophysiology and management [J]. Am J Med, 1994, 96(2): 168-79.
[4] Abbott KC, Cruess DF, Agodoa LY, et al. Early renal insufficiency and late venous thromboembolism after renal transplantation in the United States[J]. Am J Kidney D is, 2004, 43(1): 120-30.
[5] Modig JC, Malmberg PA, Etston BE. Pulmonary and circulatory reactions during total hip replacement surgery [J]. Acta Anesthesiol Scand, 1995, 19(3): 219-37.
[6] MerkusJW, BarendregtWB, vanAstenWN, et al. Changesin venous hemodynamics after renal transplantation [J]. Transpl Int,1998, 11(4): 284-7.
[7] Essler M, Hestin D, Mayeux D, et al. Factors predisposing to post renal transplant erythrocytosis: a prospective matched pair control study [J]. Clin Nephrol, 1996, 45 (2): 83.
[8] Son RS, Julian BA, Curtis JJ. Posttransplant erythrocytosis: an enigma revisited[J]. Am J Kidney Dis, 1994, 24(1):1.
[9] Cappeliez O, Peetrons P, Creteur V. Current methods in the diagnosis of deep venous thrombosis of the lower limbs [J]. Rev Med Brux,1996, 17(3): 127-31.
[10] Cavaye D, Kelly AT, Graham JG, et al. Duplex ultrasound of lower limb deep venous thrombosis[J]. Aust N Z J Surg, 1990, 60: 283-8.
[11] Cho JS, Martelli E, Mozes G, et al. Effects of thrombolysis and venous thrombectomy on valvular competence, thrombogenicity,venous wall morphology, and function[J]. J Vasc Surg, 1998, 28(5): 787-99.
[12] Bounameaux H, De Moerloose P, Sarasin FP. Optimal duration of oral anticoagulant therapy following deep vein thrombosis of lower limbs[J]. Blood Coagul Fibrinolysis, 1996, 7(5): 507-14.
[13] Mostbeck A. Diagnosis of lung embolism [J]. Acta Med Austriaca,1993, 20(1-2): 32.
[14] Alkhunaizi AM, Olyaei AJ, Barry JM, et al. Efficacy and safety of low molecular weight heparin in renal transplantation [J].Transplantation, 1998, 66(4):533-4.