Abstract: Objective To study the changes in myocardial enzyme spectrum in relation to electrocardiogram (ECG) in Salmonella food poisoning.Methods The myocardial enzyme spectrum and ECG of 56 patients with Salmonella food poisoning were examined, with 34 normal subjects serving as the control group.Results In the food poisoning group, the myocardial enzyme activities was increased in 36 cases (64.29%) within 2 days after the poisoning and the ECG of 33 cases (58.93%) showed abnormal changes within 1-4 days. The levels of creatine phosphoskinase (CPK) and α-hydroxybutyrate acid dehydrogenase (α-HBDH) in poisoning group were obviously higher than those in the control group (P<0.01).Conclusion Routine examination of myocardial enzyme spectrum and ECG helps define early changes in patients with Salmonella food poisoning for clinical treatment decision.