Abstract: Objective To identify the factors affecting ST-T segment in asymptomatic hypertensive patients. Methods The asymptomatic patients with hypertention were divided into abnormal ST-T group (n=28) and normal ST-T group (n=20), in whom the serum levels of glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), very-low-density lipoprotein cholesterol (VLDL) were measured. Results Com-pared with patients with normal ST-T segment, patients with abnormal ST-T segment had significantly higher serum levels of TC, but significantly lower HDL. The serum levels of glucose, TG, LDL, VLDL differed little between the 2 groups of pa-tients. Conclusion In asymptomatic patients with hypertension, higher serum TC level may cause or worsen ischemic my-ocardial damage, for which HDL plays a protective role.