Clinical evaluation of abdominal multiorgan transplantation

Abstract

Abstract: Objective To evaluate the clinical effect of abdominal multiorgan transplantation in patients with multiorgan failure. Methods Simultaneous kidney-pancreas transplantation (SKPT) with enteric drainage of pancreatic exocrine secretions was performed in 2 patients with type 1 diabetes and end-stage renal disease. A combined liver-kidney transplantation (CLKT) was done in a 66-year-old patient with alcoholic liver cirrhosis and uremia. Simultaneous orthotopic liver and heterotopic pancreas-duodenum transplantation (SLPT) was performed in a patient with hepatitis B, hepatocirrhosis, hepatic cellular cancer, and type 1 diabetes. Results The function of kidney grafts became normal 5 days postoperatively and insulin-independent after treatment with low dose insulin for 10 days in the 2 SKPT patients. For the CLKT patient, both transplanted organs rapidly achieved normal functions after operation but suffered-acute liver graft rejection on postoperation day 10 and the rejection was controlled after methylprednisolone pulse therapy. In the SLPT patient, insulin was withdrawn 5 days after operation, liver allograft function recovered well. All the patients are alive with stable allograft function after following-up for 29, 26, 9 and 6 months, respectively. Conclusions Abdominal multi organ transplantation was effective therapy to patients with multiple organ failure. SLPT can reduce acute pancreas rejection and promote the recovery of liver allograft.

CLC Number:

YU Li-xin, LIU Xiao-you, XU Jian, DENG Wen-feng, YE Gui-rong, FU Shao-jie, DU Chuan-fu, MA Jun-jie. Clinical evaluation of abdominal multiorgan transplantation[J]. Journal of Southern Medical University, 2004, 24(02): 148-151.

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