南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (10): 1534-.

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MK、Ki67在胃癌中异常表达及其与胃癌的临床关系

李易非，史飞涛，吴承蓉，杨芳   

  • 出版日期:2014-10-20 发布日期:2014-10-20

Differential expression of midkine and Ki67 in gastric carcinoma and the clinical
implications

  • Online:2014-10-20 Published:2014-10-20

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摘要： 目的探讨胃癌组织中中期因子（midkine，MK）和Ki67的表达，及其与临床病理学因素的关系。方法应用免疫组织化学
方法检测71 例胃癌组织及20 例胃癌癌旁形态学正常组织中MK、Ki67 表达。结果MK、Ki67 在胃癌组织中的表达水平
（76.1%，73.2%）均显著高于在癌旁形态学正常胃组织中的表达水平（0，5%）（P<0.01）；胃癌组织中MK、Ki67的阳性表达与肿瘤
浸润深度、淋巴结转移及病理分期密切相关（P<0.05）；MK与Ki67表达呈正相关性（P<0.05），MK、Ki67蛋白表达阳性的患者预
后较差。结论MK、Ki67在胃癌组织中表达水平高于胃癌旁组织，两者在胃癌的形成和进展中起重要作用，其阳性表达与胃癌
患者多项临床病理指标相关，可能与胃癌患者预后密切相关。

Abstract: Objective To investigate the expressions of midkine (MK) and Ki67 in gastric carcinoma (GC) and their relation with
the clinicopathologic characteristics. Methods The expressions of MK and Ki67 in 71 GC and 20 adjacent normal tissues were
evaluated by immunohistochemistry. Results The expressions of MK and Ki67 were significantly higher in GC than in adjacent
normal tissues (76.1% vs 0, and 73.2% vs 5% , respectively, P<0.05). MK and Ki67 expressions were correlated with the
infiltration depth, lymph node metastasis and TNM stage (P<0.05), and a significant correlation was found between MK and
Ki67 expressions (P<0.05). Conclusion GC tissues have high expressions of MK and Ki67, indicating that MK and Ki67 play
important roles in promoting the tumorigenesis and progression of GC.