广东汉族人群杀伤免疫球蛋白样受体基因的表达频率

南方医科大学学报 ›› 2004, Vol. 24 ›› Issue (12): 1416-1418.

广东汉族人群杀伤免疫球蛋白样受体基因的表达频率

尹晓林¹, 郭坤元¹, 马红京¹, 尚振川¹, 肖露露², 叶欣², 赵阳²

1. 南方医科大学珠江医院血液科, 广东, 广州, 510282;
2. 广州组织配型中心, 广东, 广州, 510095

出版日期:2004-12-20 发布日期:2004-12-20
基金资助:
收稿日期:2004-1-16。
作者简介:尹晓林(1972- ),男,1998年毕业于南方医科大学,硕士,主治医师,电话:020-88129866,E-mail:yin-xl@163.com.
通讯作者:郭坤元,教授,博士生导师,南方医科大学珠江医院血液科,电话:020-61643187,E-mail:gzyuan@pub.guangzhou.gd.cn

Killer immunoglobulin-like receptor gene distribution in Guangdong Han population

YIN Xiao-lin¹, GUO Kun-yuan¹, MA Hong-jing¹, SHANG Zheng-chuan¹, XIAO Lu-lu², YE Xin², ZHAO Yang²

1. 南方医科大学珠江医院血液科, 广东, 广州, 510282;
2. 广州组织配型中心, 广东, 广州, 510095

Online:2004-12-20 Published:2004-12-20

摘要/Abstract

摘要： 目的检测杀伤免疫球蛋白样受体(KIR)基因在广东汉族人群中的分布。方法对96例广东汉族以SSP法检测其KIR表型,统计不同KIR基因在人群中的表现频率,并与白种人、北印度人、日本人比较。结果不同KIR的表现表率分别为:2DL1(0.85)、2DL2(0.12)、2DL3(0.58)、2DL4(1)、2DL5(0.24)、3DL1(0.96)、3DL2(1)、3DL3(1)、2DP1(0.97)、2DP2(0.98)、2DS1(0.10)、2DS2(0.30)、2DS3(0.02)、2DS4(0.28)、1D(0.65)、2DS5(0.19)、3DS1(0.23)。比较同一HLA配体相应的KIR,抑制性KIR频率均高于活化性KIR。与白种人和北印度人相比,除KIR2DS4外,广东汉族人群的活化性KIR频率均较低。结论不同KIR基因在广东汉族人中有不同的表达频率。与其他人种比较,KIR基因的分布有着明显的种族差异。

Abstract: Objective To investigate the distribution of killer immunoglobulin-like receptor (KIR) gene in Guangdong Han population. Methods KIR phenotype was examined by PCR with sequence-specific primers in 96 subjects of Han nationality in Guangdong Province of China, and KIR frequency was calculated and compared with those in Caucasian, north Indian and Japanese populations. Result The gene expression frequency of KIR in Guangdong Han people was 2DL1(0.85), 2DL2(0.12), 2DL3(0.58), 2DL4(1), 2DL5(0.24), 3DL1(0.96), 3DL2(1), 3DL3(1), 2DP1(0.97), 2DP2(0.98), 2DS1(0.10), 2DS2(0.30), 2DS3(0.02), 2DS4(0.28), 1D(0.65), 2DS5(0.19), and 3DS1(0.23) respectively. Comparison of the KIR recognizing the same HLA ligand suggested significantly higher expression frequency of inhibitory KIR than that of activating KIR. Compared with Caucasian and north Indian populations, Guangdong Han population had significantly lower expression frequency of activating KIR gene with the exception of KIR2DS4. Conclusion Different KIR genes have different expression frequencies in Guangdong Han population, and KIR gene distribution varies between populations of different races.

中图分类号:

尹晓林¹, 郭坤元¹, 马红京¹, 尚振川¹, 肖露露², 叶欣², 赵阳². 广东汉族人群杀伤免疫球蛋白样受体基因的表达频率[J]. 南方医科大学学报, 2004, 24(12): 1416-1418.

YIN Xiao-lin¹, GUO Kun-yuan¹, MA Hong-jing¹, SHANG Zheng-chuan¹, XIAO Lu-lu², YE Xin², ZHAO Yang². Killer immunoglobulin-like receptor gene distribution in Guangdong Han population[J]. Journal of Southern Medical University, 2004, 24(12): 1416-1418.

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