Abstract: Objective To analyze the clinical significance of syndecan binding protein (SDCBP) expression in human colorectal
carcinoma (CRC) and its value in predicting the postoperative survival of the patients. Methods The follow-up data for 10
years were collected from 109 primary CRC patients with immunohistochemical data of SDCBP expression in the tumor
tissues. The relationship between SDCBP expression and the clinical factors was analyzed, and survival analysis was
performed using the Kaplan-Meier and Cox regression analysis models. Results SDCBP expression in CRC was significantly
associated with the postoperative survival time (χ2=8.336, P=0.004) and lymph node metastasis (P=0.001) of the patients, but not
with age, gender, depth of invasion, tissue differentiation or histological type of the tumor. Kaplan-Meier survival curves
showed that the patients expression high levels of SDCBP in the CRC tissues had a significantly shorter postoperative mean
survival time and a lower 7-year survival rate than those with low SDCBP expressions [52.300±6.508 vs 86.184±5.358 months,
(38.6±6.4)% vs (61.5±6.7)%; χ2=10.585, P=0.001]. Multivariate Cox analysis revealed that a high expression of SDCBP (B=0.605, P=
0.034) and lymph node metastasis (B=0.677, P=0.013) were the main factors related to death in CRC patients. Conclusion
SDCBP expression level can serve as an indicator for lymph node metastasis, TNM staging, and outcome prediction of CRC.